Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations
文献类型：期刊论文
| 作者 | Lv,Jun-Jiang; Yu,Shan ; Xin,Ying; Cheng,Rong-Rong; Zhu,Hong-Tao; Wang,Dong; Yang,Chong-Ren; Xu,Min; Zhang,Ying-Jun
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2015-09-01 |
| 卷号 | 117页码:123-134 |
| 关键词 | Yu Gan Zi Phyllanthus emblica Euphorbiaceae ECD calculation Antiviral Norbisabolane sesquiterpenoid glycosides Phyllaemblicins |
| 英文摘要 | In an effort to identify anti-viral and cytotoxic compounds from Phyllanthus spp., 14 highly oxygenated norbisabolane sesquiterpenoids, phyllaemblicins H1-H14, were isolated from the roots of Phyllanthus emblica Linn, along with phyllaemblicins B and C and glochicoccinoside D. Their structures were determined on the basis of detailed spectroscopic analysis and chemical methods. Determination of absolute configurations of these compounds was facilitated by theoretical calculations of electronic circular dichroism (ECD) spectra using time-dependent density functional theory (TDDFT) for the aglycone components, and pre-column derivative/chiral HPLC analysis for the monosaccharides. The known glochicoccinoside D displayed potent activity against influenza A virus strain H3N2 and hand, foot and mouth virus EV71, with IC50 values of 4.5 +/- 0.6 and 2.6 +/- 0.7 mu g/ml, respectively. Phyllaemblicin H1 showed moderate cytotoxicity against human cancer cell lines A-549 and SMMC-7721, with IC50 values of 4.7 +/- 0.7 and 9.9 +/- 1.3 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | ROOTS ; NORSESQUITERPENOIDS ; ACIDUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361253300014 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25140]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Lv,Jun-Jiang,Yu,Shan,Xin,Ying,et al. Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations[J]. PHYTOCHEMISTRY,2015,117:123-134. |
| APA | Lv,Jun-Jiang.,Yu,Shan.,Xin,Ying.,Cheng,Rong-Rong.,Zhu,Hong-Tao.,...&Zhang,Ying-Jun.(2015).Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations.PHYTOCHEMISTRY,117,123-134. |
| MLA | Lv,Jun-Jiang,et al."Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations".PHYTOCHEMISTRY 117(2015):123-134. |
入库方式： OAI收割
来源：昆明植物研究所
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