Structural Characterization and Immunostirnulatory Activity of a Homogeneous Polysaccharide from Sinonovacula constricta
文献类型：期刊论文
| 作者 | Yuan,Qingxia; Zhao,Longyan ; Cha,Qianqian; Sun,Yi; Ye,Hong; Zeng,Xiaoxiong
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2015-09-16 |
| 卷号 | 63期号:36页码:7986-7994 |
| 关键词 | Sinonovacula constricta polysaccharide structure immunomodulatory activity |
| 英文摘要 | Sinonovacula constricta has been widely used as a health food and medicine in China, Japan, and Korea. In the present study, a water-soluble polysaccharide fraction (SCP-1) was prepared from S. constricta by enzyme-assisted extraction and purification of chromatography with DEAE-52 cellulose anion-exchange column and Sephadex G-100 size exclusion column. On the basis of the analytical results of high-performance liquid chromatography, Fourier transform-infrared spectroscopy, methylation analysis, and NMR spectroscopy, SCP-1 was found to have an average molecular weight of 15.63 kDa and a linear backbone of (1 -> 4)-linked alpha-D-Glcp residue with one branch, alpha-D-Glcp, attached to the main chain by a (1 -> 6) glycosidic bond at every five alpha-D-Glcp units. Furthermore, it was found that SCP-1 could significantly increase the viability of macrophages, enhance the capability of macrophage phagocytosis, increase the activity of acid phosphatase, and promote the production of nitric oxide, mouse tumor necrosis factor (TNF)-alpha, mouse interferon (IFN)-gamma, and mouse interleuldn (IL)-1 beta. The results suggest that SCP-1 possesses potent immunomodulating effect and may be explored as a potential biological response modifier. |
| 类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
| 关键词[WOS] | ACTIVITY IN-VITRO ; MACROPHAGE IMMUNOMODULATORY ACTIVITY ; ALPHA-D-GLUCAN ; MORUS-ALBA L. ; IMMUNOSTIMULATORY ACTIVITY ; RAZOR CLAM ; HYRIOPSIS-CUMINGII ; GLOSSAULAX-DIDYMA ; SEASONAL-CHANGES ; IMMUNE-RESPONSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361502000012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25141]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yuan,Qingxia,Zhao,Longyan,Cha,Qianqian,et al. Structural Characterization and Immunostirnulatory Activity of a Homogeneous Polysaccharide from Sinonovacula constricta[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2015,63(36):7986-7994. |
| APA | Yuan,Qingxia,Zhao,Longyan,Cha,Qianqian,Sun,Yi,Ye,Hong,&Zeng,Xiaoxiong.(2015).Structural Characterization and Immunostirnulatory Activity of a Homogeneous Polysaccharide from Sinonovacula constricta.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,63(36),7986-7994. |
| MLA | Yuan,Qingxia,et al."Structural Characterization and Immunostirnulatory Activity of a Homogeneous Polysaccharide from Sinonovacula constricta".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63.36(2015):7986-7994. |
入库方式： OAI收割
来源：昆明植物研究所
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