Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots
文献类型：期刊论文
| 作者 | Liu,JieQing; Yang,YuanFeng; Xia,JianJun; Li,XuYang; Li,ZhongRong; Zhou,Lin; Qiu,MingHua
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 117页码:462-468 |
| 关键词 | Jatropha curcas Euphorbiaceae Diterpenoids Cytotoxic activity |
| 英文摘要 | An investigation of phytochemicals from the roots of Jatropha curcas cv. nigroviensrugosus resulted in the isolation of twenty diterpenoids, including lathyranlactone, an unusual diterpenoid lactone possessing a 5/13/3 tricyclic skeleton, jatrocurcasenones A-E and jatrophodiones B-E, as well as 10 known analogues. All isolates were evaluated for cytotoxicity against the HL-60, SMMC-772, A-549, MCF-7 and SW480 human tumor cell lines using the MTS viability assay. Four of the known analogues showed cytotoxic activity in these cell lines, with IC50 values ranging from 2.0 to 23.0 mu M. Moreover, the assessment of their cytotoxic structure-activity relationships showed the epoxy ring between C-5 and C-6 and the hydroxyl group at C-2 were the key functionalities for cytotoxicity. (C) 2015 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | SEED OIL ; EUPHORBIA-FALCATA ; 12-DEOXY-16-HYDROXYPHORBOL ; GROSSIDENTATA ; ESTERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361253300047 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25142]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu,JieQing,Yang,YuanFeng,Xia,JianJun,et al. Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots[J]. PHYTOCHEMISTRY,2015,117:462-468. |
| APA | Liu,JieQing.,Yang,YuanFeng.,Xia,JianJun.,Li,XuYang.,Li,ZhongRong.,...&Qiu,MingHua.(2015).Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots.PHYTOCHEMISTRY,117,462-468. |
| MLA | Liu,JieQing,et al."Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots".PHYTOCHEMISTRY 117(2015):462-468. |
入库方式： OAI收割
来源：昆明植物研究所
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