Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase
文献类型：期刊论文
| 作者 | Zhang,Ji; Yan,Yi-Jun; An,Jing; Huang,Sheng-Xiong; Wang,Xiang-Jing; Xiang,Wen-Sheng |
| 刊名 | MICROBIAL CELL FACTORIES
 |
| 出版日期 | 2015-09-24 |
| 卷号 | 14 |
| 关键词 | 25-Ethyl ivermectin 25-Methyl ivermectin Domain swap Insecticidal activity |
| 英文摘要 | Background: Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The biosynthetic gene clusters of avermectin and milbemycin have been identified and the biosynthetic pathways have been elucidated. Combinatorial biosynthesis by domain swap provides an efficient strategy to generate chemical diversity according to the module polyketide synthase (PKS) assembly line. |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | STREPTOMYCES-BINGCHENGGENSIS ; COMBINATORIAL BIOSYNTHESIS ; BIOLOGICAL-ACTIVITIES ; MAIN COMPONENTS ; GENE-CLUSTER ; DORAMECTIN ; AVERMITILIS ; DERIVATIVES ; A3/A4 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361650700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25153]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang,Ji,Yan,Yi-Jun,An,Jing,et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase[J]. MICROBIAL CELL FACTORIES,2015,14. |
| APA | Zhang,Ji,Yan,Yi-Jun,An,Jing,Huang,Sheng-Xiong,Wang,Xiang-Jing,&Xiang,Wen-Sheng.(2015).Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase.MICROBIAL CELL FACTORIES,14. |
| MLA | Zhang,Ji,et al."Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase".MICROBIAL CELL FACTORIES 14(2015). |
入库方式： OAI收割
来源：昆明植物研究所
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