Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii
文献类型：期刊论文
| 作者 | Zhu,Hucheng; Chen,Chunmei; Tong,Qingyi; Chen,Xintao; Yang,Jing ; Liu,Junjun; Sun,Bin; Wang,Jianping; Yao,Guangmin; Luo,Zengwei
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-10-06 |
| 卷号 | 5 |
| 英文摘要 | Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H-M (1-6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7-11). The structures of 1-6 were established by extensive spectroscopic analyses, including HRESIMS and NMR. In addition, the absolute configurations of these new compounds were determined by electronic circular dichroism (ECD) calculations. Compounds 1 and 2 represent the first examples of PPAPs possessing a unique gamma-lactone ring at C-23, while 3-6 differed from normal PPAPs with an unprecedented 1,2-dioxane ring. Compounds 1-7 were evaluated for their cytotoxic activities against a panel of human cancer cell lines in vitro, of which 3, 4, and 6 exhibited significant cytotoxic activities with IC50 values ranging from 0.56 to 3.00 mu M. Moreover, compound 3 induces leukemia cell apoptotic death, evidenced by activation of caspase-3, degradation of PARP, up-regulation of Bax, and down-regulation of Bcl-2 and Bcl-xl. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES ; PHLOROGLUCINOL DERIVATIVES ; BENZOPHENONE DERIVATIVES ; UNIQUE FAMILY ; CYCLIZATION ; GUTTIFERAE ; SKELETON ; ASCYRON ; CORES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362260000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25162]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu,Hucheng,Chen,Chunmei,Tong,Qingyi,et al. Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Zhu,Hucheng.,Chen,Chunmei.,Tong,Qingyi.,Chen,Xintao.,Yang,Jing.,...&Zhang,Yonghui.(2015).Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii.SCIENTIFIC REPORTS,5. |
| MLA | Zhu,Hucheng,et al."Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：昆明植物研究所
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