Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide
文献类型：期刊论文
| 作者 | Zhao,Hongmei; Zeng,Guangzhi; Zhao,Simeng; Xu,Junju; Kong,Lingmei; Li,Yan ; Tan,Ninghua; Yang,Shengchao
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2015-10-15 |
| 卷号 | 25期号:20页码:4572-4575 |
| 关键词 | Zingiberaceae Hedychium longipetalum Labdane diterpenes Inhibition of NO production Cytotoxicity |
| 英文摘要 | Three new labdane diterpenes, hedylongnoids A (1), B (2) and C (3), were isolated from the rhizomes of Hedychium longipetalum, together with three known ones yunnancoronarin A (4), hedyforrestin C (5) and hedyforrestin B (6). Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Compounds 1-6 exhibited inhibitory effects against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.56 to 7.50 mu g/ml, and 3-6 showed cytotoxicities against cancer cell lines SGC-7901 and Hela with IC50 values ranging from 6.21 to 14.53 mu g/ml and from 6.58 to 14.83 mu g/ml, respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | SPICATUM ; RHIZOMES ; CORONARIUM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362102200039 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25164]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhao,Hongmei,Zeng,Guangzhi,Zhao,Simeng,et al. Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(20):4572-4575. |
| APA | Zhao,Hongmei.,Zeng,Guangzhi.,Zhao,Simeng.,Xu,Junju.,Kong,Lingmei.,...&Yang,Shengchao.(2015).Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(20),4572-4575. |
| MLA | Zhao,Hongmei,et al."Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.20(2015):4572-4575. |
入库方式： OAI收割
来源：昆明植物研究所
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