Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia
文献类型：期刊论文
| 作者 | Lia,Zhen-Jie; Wan,Chun-Ping; Cai,Le; Li,Shu-Quan; Zheng,Xi; Qi,Yan; Dong,Jian-Wei; Yin,Tian-Peng; Zhou,Zhi-Xian; Tan,Ning-Hua |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 13页码:246-251 |
| 关键词 | Pyrus pashia Triterpenoid Monoterpenoid Cytotoxic activity |
| 英文摘要 | Twenty terpenoids, including a new triterpenoid (1) and a new monoterpenoid (20), were isolated from the branches and leaves of Pyrus pashia. The structures of two new compounds were determined to be 2 alpha, 3 beta, 27-trihydroxyolean-12-en-28-oic acid (1) and (4 alpha)-3-(5,5-dimethyltetrahydrofuranyl)-1-buten-3-ol 3-O-beta-D-glucopyranoside (20) on the basis of spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and chemical method. Some of the isolated compounds were evaluated for their cytotoxic activity against a panel of human cancer cell lines by MTT assay, using cisplatin as a positive control. Compound 14 exhibited cytotoxic activities against A549 (IC50 = 19.18 +/- 4.26 mu M), Hela (IC50 = 12.56 +/- 3.89 mu M), SGC7901 (IC50 = 10.48 +/- 1.95 mu M) and NHI-1975 (IC50 = 7.38 +/- 2.31 mu M) cell lines as well as compound 12 displayed cytotoxic activities against A549 (IC50 = 14.71 +/- 1.47 mu M) and Hela (IC50 = 12.22 +/- 1.88 mu M) cell lines. (C) 2015 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | TRITERPENOID SAPONINS ; ANTIFEEDANT ACTIVITY ; ERIOBOTRYA-JAPONICA ; URSOLIC ACID ; INHIBITORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362174600043 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25167]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Lia,Zhen-Jie,Wan,Chun-Ping,Cai,Le,et al. Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia[J]. PHYTOCHEMISTRY LETTERS,2015,13:246-251. |
| APA | Lia,Zhen-Jie.,Wan,Chun-Ping.,Cai,Le.,Li,Shu-Quan.,Zheng,Xi.,...&Ding,Zhong-Tao.(2015).Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia.PHYTOCHEMISTRY LETTERS,13,246-251. |
| MLA | Lia,Zhen-Jie,et al."Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia".PHYTOCHEMISTRY LETTERS 13(2015):246-251. |
入库方式： OAI收割
来源：昆明植物研究所
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