A fragmentation study on four C19-diterpenoid alkaloids by electrospray ionization ion-trap time-of-flight tandem mass spectrometry
文献类型：期刊论文
| 作者 | Chen,Xing-Long; Geng,Chang-An; Chen,Ji-Jun
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2015-09-02 |
| 卷号 | 17期号:9页码:915-929 |
| 关键词 | Ranunculaceae Aconitum HR-ESI-IT-TOF-MSn Fragmentation rules C-19-diterpenoid alkaloids |
| 英文摘要 | High-resolution electrospray ionization ion-trap time-of-flight tandem mass spectrometry (HR-ESI-IT-TOF-MSn) in positive-ion mode was used to determine the accurate masses and fragmentation pathways of four C-19-diterpenoid alkaloids, aconitine (1), yunnaconitine (2), crassicauline A (3), and benzoylmesaconine (4). The [M+H](+) ions of compounds 1-4 were readily observed in conventional single-stage mass spectrometry. Based on the MS1-6 analyses, detailed fragmentation rules of the four compounds were proposed. The neutral losses of AcOH, MeOH, H2O, CO, C2H4, PhCOOH and p-OMePhCOOH segments were the characteristic eliminations from the precursor ions due to the presence of acetyl, methoxyl, hydroxyl, N-ethyl, benzoyl and p-methoxyl-benzoyl units in the structures. Benefited from the high resolution of the mass analyzer, the loss of 28Da corresponding to CO or CH4 segment in product ions was unambiguously distinguished. The losing sequence of the main substituent groups was summarized as: C(8)-acetyl>C(16)-methotyl>C(15)-hydroxyl>C(6)-methoxyl>C(1)-methoxyl/C(3)-hydroxyl>C(18)-methoxyl>>C(13)-hydroxyl. The sequential loss of (16)-methoxyl moiety and CO (generating from enol-ketone tautomerism) groups could be recognized as the characteristic eliminations for the compounds with C(16)-methoxyl and C(15)-hydroxyl groups simultaneously. The application of HR-ESI-IT-TOF-MSn technique to investigate the fragmentation of C-19-diterpenoid alkaloids provided useful information to understand their fragmentation behaviors. |
| 类目[WOS] | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | ACONITUM ALKALOIDS ; DITERPENOID ALKALOIDS ; IDENTIFICATION ; MESACONITINE ; DERIVATIVES ; FLOWERS ; ROOTS ; RADIX ; HERB |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361969800008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25181]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen,Xing-Long,Geng,Chang-An,Chen,Ji-Jun. A fragmentation study on four C19-diterpenoid alkaloids by electrospray ionization ion-trap time-of-flight tandem mass spectrometry[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(9):915-929. |
| APA | Chen,Xing-Long,Geng,Chang-An,&Chen,Ji-Jun.(2015).A fragmentation study on four C19-diterpenoid alkaloids by electrospray ionization ion-trap time-of-flight tandem mass spectrometry.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(9),915-929. |
| MLA | Chen,Xing-Long,et al."A fragmentation study on four C19-diterpenoid alkaloids by electrospray ionization ion-trap time-of-flight tandem mass spectrometry".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.9(2015):915-929. |
入库方式： OAI收割
来源：昆明植物研究所
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