Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti
文献类型：期刊论文
| 作者 | Zhu,Hucheng; Chen,Chunmei; Wang,Jianping; Li,Xiao-Nian; Wei,Guangzheng; Guo,Yi; Yao,Guangmin; Luo,Zengwei; Zhang,Jinwen; Xue,Yongbo |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 12期号:10页码:1547-1553 |
| 关键词 | Anti-HIV activity Cytotoxic activity Indole alkaloids Penicamedine A Penicillium camemberti X-Ray crystallography |
| 英文摘要 | A highly oxygenated hexacyclic indole alkaloid, penicamedine A (1), bearing a rare furan ring, was isolated from the culture broth of Penicillium camemberti, together with two known analogs, iso--cyclopiazonic acid (2) and cyclopiazonic acid (3). The structure of 1 was elucidated by comprehensive spectroscopic analyses including NMR and HR-ESI-MS. Its absolute configuration was further confirmed unambiguously by single-crystal X-ray diffraction analysis. Compound 1 was evaluated for anti-HIV activity with p24 assays and tested for cytotoxic activities against five human cancer cell lines, including HL-60, SMMC-7721, A-549, MCF-7, SW480, and the immortalized non-cancerous human pulmonary epithelial cell line BEAS-2B by MTS method. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | CYCLOPIAZONIC ACID ; DITERPENOIDS ; POLYKETIDES ; DERIVATIVES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362956100006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25195]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu,Hucheng,Chen,Chunmei,Wang,Jianping,et al. Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti[J]. CHEMISTRY & BIODIVERSITY,2015,12(10):1547-1553. |
| APA | Zhu,Hucheng.,Chen,Chunmei.,Wang,Jianping.,Li,Xiao-Nian.,Wei,Guangzheng.,...&Zhang,Yonghui.(2015).Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti.CHEMISTRY & BIODIVERSITY,12(10),1547-1553. |
| MLA | Zhu,Hucheng,et al."Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti".CHEMISTRY & BIODIVERSITY 12.10(2015):1547-1553. |
入库方式： OAI收割
来源：昆明植物研究所
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