Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives
文献类型：期刊论文
| 作者 | Chen, Gang1,2; Hao, Xiaojiang2,3,4 ; Wang, Ye3,4; Mu, Shuzhen3,4
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| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2015 |
| 卷号 | 12期号:10页码:813-818 |
| 关键词 | Isatin derivative synthesis anti-tumor neuro-protection even-odd effect |
| 英文摘要 | In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship. |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364520600004 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25235]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Gang,Hao, Xiaojiang,Wang, Ye,et al. Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2015,12(10):813-818. |
| APA | Chen, Gang,Hao, Xiaojiang,Wang, Ye,&Mu, Shuzhen.(2015).Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives.LETTERS IN DRUG DESIGN & DISCOVERY,12(10),813-818. |
| MLA | Chen, Gang,et al."Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives".LETTERS IN DRUG DESIGN & DISCOVERY 12.10(2015):813-818. |
入库方式： OAI收割
来源：昆明植物研究所
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