Synthesis, Cytoprotective and Anti-tumor Activities of Isatin Schiff Bases
文献类型：期刊论文
| 作者 | Chen, Gang1,2; Meng, Mei1; Zhang, Yu2 ; Hao, Xiaojiang2,3,4; Wang, Ye3,4; Mu, Shuzhen3,4
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| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2015 |
| 卷号 | 12期号:10页码:802-805 |
| 关键词 | Isatin synthesis schiff base structure cytoprotective anti-tumor |
| 英文摘要 | A series of simple isatin Schiff bases were synthesized through the condensation reaction. These isatin Schiff bases were characterized by NMR and MS, and the structure was discussed. Then, the cytoprotective and anti-tumor activities of these compounds were evaluated. The results show that several compounds show protection activity on the apoptosis of PC12 cells induced by H2O2, which are more effective than that of (+/-) alpha-Tocophreol (VE) and isatin. Besides, some compounds also show more potent anti-tumor activity against A549 and P388 cell lines than that of isatin. |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | DERIVATIVES ; ANTICANCER ; DESIGN ; POTENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364520600002 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25236]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Gang,Meng, Mei,Zhang, Yu,et al. Synthesis, Cytoprotective and Anti-tumor Activities of Isatin Schiff Bases[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2015,12(10):802-805. |
| APA | Chen, Gang,Meng, Mei,Zhang, Yu,Hao, Xiaojiang,Wang, Ye,&Mu, Shuzhen.(2015).Synthesis, Cytoprotective and Anti-tumor Activities of Isatin Schiff Bases.LETTERS IN DRUG DESIGN & DISCOVERY,12(10),802-805. |
| MLA | Chen, Gang,et al."Synthesis, Cytoprotective and Anti-tumor Activities of Isatin Schiff Bases".LETTERS IN DRUG DESIGN & DISCOVERY 12.10(2015):802-805. |
入库方式： OAI收割
来源：昆明植物研究所
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