ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses
文献类型:期刊论文
作者 | Wang,Wei-Guang; Yang,Jin; Wu,Hai-Yan; Kong,Ling-Mei; Su,Jia; Li,Xiao-Nian; Du,Xue; Zhan,Rui; Zhou,Min; Li,Yan![]() |
刊名 | TETRAHEDRON
![]() |
出版日期 | 2015-12-02 |
卷号 | 71期号:48页码:9161-9171 |
关键词 | ent-Kaurane Diterpenoids Isodon |
英文摘要 | In this report, a new cytotoxic group, a 15-oxo-16 alpha-H-17-methoxy (or ethoxy)- unit, was suggested from the structure-activity relationship analyses of 39 ent-kaurane diterpenoids, including 17 new compounds (neolaxiflorins I-Y, 1-17) isolated from the leaves of Isodon eriocalyx var. laxiflora using an in vitro cytotoxicity assay against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human cancer cell lines. This discovery is counter to the rule that the alpha,beta-unsaturated ketone (C-15-C-16-C-17) unit is indispensable for cytotoxicity of the ent-kauranoids. Furthermore, portions of the isolates exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. The NF-kappa B inhibitory activity assay suggests a potential novel cytotoxic mechanism for compounds 9 and 22. (C) 2015 Elsevier Ltd. All rights reserved. |
类目[WOS] | Chemistry, Organic |
研究领域[WOS] | Chemistry |
关键词[WOS] | NF-KAPPA-B ; DNA-BINDING ACTIVITY ; LEUKEMIC-CELLS ; DITERPENOIDS ; CANCER ; ACTIVATION ; TERPENOIDS ; PATHWAYS ; ORIDONIN ; DIFFERENTIATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000364885800015 |
源URL | [http://ir.kib.ac.cn/handle/151853/25243] ![]() |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
推荐引用方式 GB/T 7714 | Wang,Wei-Guang,Yang,Jin,Wu,Hai-Yan,et al. ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses[J]. TETRAHEDRON,2015,71(48):9161-9171. |
APA | Wang,Wei-Guang.,Yang,Jin.,Wu,Hai-Yan.,Kong,Ling-Mei.,Su,Jia.,...&Sun,Han-Dong.(2015).ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses.TETRAHEDRON,71(48),9161-9171. |
MLA | Wang,Wei-Guang,et al."ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses".TETRAHEDRON 71.48(2015):9161-9171. |
入库方式: OAI收割
来源:昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。