RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation
文献类型：期刊论文
| 作者 | Leung,Hoi-Wing; Zhao,Si-Meng; Yue,Grace Gar-Lee; Lee,Julia Kin-Ming; Fung,Kwok-Pui; Leung,Ping-Chung; Tan,Ning-Hua; Lau,Clara Bik-San |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-11-23 |
| 卷号 | 5 |
| 英文摘要 | Cancer cells acquire invasive ability to degrade and adhere to extracellular matrix (ECM) and migrate to adjacent tissues. This ultimately results metastasis. Hence, the present study investigated the in vitro effects of cyclopeptide glycoside, RA-XII on cell adhesion, invasion, proliferation and matrix degradation, and its underlying mechanism in murine breast tumour cells, 4T1. The effect of RA-XII on tumour growth and metastasis in 4T1-bearing mice was also investigated. Our results showed that RA-XII inhibited tumour cell adhesion to collagen, fibronectin and laminin, RA-XII also reduced the expressions of vascular cell adhesion molecule, intracellular adhesion molecule and integrins, and integrin binding. In addition, RA-XII significantly inhibited breast tumour cell migration via interfering cofilin signaling and chemokine receptors. The activities of matrix metalloproteinase-9 and urokinase-type of plasminogen activator, and the expressions of ECM-associated proteinases were attenuated significantly by RA-XII. Furthermore, RA-XII induced G1 phase arrest and inhibited the expressions of cyclins and cyclin-dependent kinases. RA-XII inhibited the expressions of molecules in PI3K/AKT, NF-kappaB, FAK/pSRC, MAPK and EGFR signaling. RA-XII was also shown to have anti-tumour, anti-angiogenic and anti-metastatic activities in metastatic breast tumour-bearing mice. These findings strongly suggested that RA-XII is a potential anti-metastatic agent for breast cancer. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CANCER CELLS ; CYCLIN D1 ; PLASMINOGEN-ACTIVATOR ; THERAPEUTIC TARGET ; RUBIA-YUNNANENSIS ; CARCINOMA ; EXPRESSION ; MIGRATION ; INTEGRIN ; PROGRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365239400003 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25252]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Leung,Hoi-Wing,Zhao,Si-Meng,Yue,Grace Gar-Lee,et al. RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Leung,Hoi-Wing.,Zhao,Si-Meng.,Yue,Grace Gar-Lee.,Lee,Julia Kin-Ming.,Fung,Kwok-Pui.,...&Lau,Clara Bik-San.(2015).RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.SCIENTIFIC REPORTS,5. |
| MLA | Leung,Hoi-Wing,et al."RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：昆明植物研究所
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