Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization
文献类型：期刊论文
| 作者 | Zhou, Min; Li, Xing-Ren; Tang, Jian-Wei; Liu, Yang; Li, Xiao-Nian; Wu, Bin; Qin, Hong-Bo ; Du, Xue; Li, Li-Mei; Wang, Wei-Guang
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015-12-18 |
| 卷号 | 17期号:24页码:6062-6065 |
| 英文摘要 | Scopariusicides A (1) and B (2), two novel immunosuppressive unsymmetrical cyclobutane derivatives, were isolated from the aerial parts of Isodon scoparius. Moreover, based on the results of phytochemical investigation, a concise stereocontrolled synthesis of scopariusicide A and its analogues with enhanced biological activities was efficiently achieved using the main diterpenoid (3) isolated from this plant as a readily available starting material. A crossed intermolecular [2 + 2] photocycloaddition and a Pd-catalyzed sp3 C-H bond beta-arylation were used synergistically to access the highly congested unsymmetrical cyclobutane core with four contiguous stereocenters. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ORGANIC-SYNTHESIS ; ISODON-SCOPARIUS ; ARYLATION ; PIPERARBORENINES ; ACTIVATION ; REVISION ; BONDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366878300032 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25330]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhou, Min,Li, Xing-Ren,Tang, Jian-Wei,et al. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization[J]. ORGANIC LETTERS,2015,17(24):6062-6065. |
| APA | Zhou, Min.,Li, Xing-Ren.,Tang, Jian-Wei.,Liu, Yang.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2015).Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization.ORGANIC LETTERS,17(24),6062-6065. |
| MLA | Zhou, Min,et al."Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization".ORGANIC LETTERS 17.24(2015):6062-6065. |
入库方式： OAI收割
来源：昆明植物研究所
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