Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity
文献类型：期刊论文
| 作者 | Wang, Zhe ; Zhao, Si-Meng; Zhao, Li-Mei; Chen, Xiao-Qiang; Zeng, Guang-Zhi; Tan, Ning-Hua
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| 刊名 | PLOS ONE
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| 出版日期 | 2015-12-22 |
| 卷号 | 10期号:12 |
| 英文摘要 | One new cyclic hexapeptide named rubipodanin A (1), which is the first identified natural N-desmonomethyl Rubiaceae-type cyclopeptide, together with six known Rubiaceae-type cyclopeptides (2-7) were obtained using the TLC cyclopeptide protosite detection method with ninhydrin from the roots and rhizomes of Rubia podantha. The cyclopeptide structures were elucidated by extensive spectroscopic analysis, including 1D-NMR, 2D-NMR, IR, UV and MS. The solution conformation and biological activities of 1 and RA-V (4) were evaluated, and the results demonstrated that the N-9-methyl group plays a vital role in the maintenance of the conformation and bioactivity. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ANTITUMOR CYCLIC HEXAPEPTIDES ; CYTOTOXIC BICYCLIC HEXAPEPTIDES ; SUBUNIT FUNCTIONAL ROLES ; BREAST-CANCER CELLS ; CORDIFOLIA L ; RA-VII ; DEOXYBOUVARDIN ; YUNNANENSIS ; IDENTIFICATION ; RUBIYUNNANINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367092500017 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25332]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Zhe,Zhao, Si-Meng,Zhao, Li-Mei,et al. Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity[J]. PLOS ONE,2015,10(12). |
| APA | Wang, Zhe,Zhao, Si-Meng,Zhao, Li-Mei,Chen, Xiao-Qiang,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2015).Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity.PLOS ONE,10(12). |
| MLA | Wang, Zhe,et al."Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity".PLOS ONE 10.12(2015). |
入库方式： OAI收割
来源：昆明植物研究所
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