Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata
文献类型：期刊论文
| 作者 | Gao, Yuan; Yu, Ai-Lin; Li, Gen-Tao; Hai, Ping; Li, Yan ; Liu, Ji-Kai; Wang, Fei
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 107页码:44-48 |
| 关键词 | Rauvolfia verticillata Monoterpenoid indole alkaloid Rauvovertine Cytotoxicity |
| 英文摘要 | Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. (C) 2015 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | STRUCTURE ELUCIDATION ; RAUWOLFIA ; SARPAGINE ; IDENTIFICATION ; CONSTITUENTS ; SERPENTINA ; PERAKSINE ; LEAVES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367113000006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25346]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Yu, Ai-Lin,Li, Gen-Tao,et al. Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata[J]. FITOTERAPIA,2015,107:44-48. |
| APA | Gao, Yuan.,Yu, Ai-Lin.,Li, Gen-Tao.,Hai, Ping.,Li, Yan.,...&Wang, Fei.(2015).Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.FITOTERAPIA,107,44-48. |
| MLA | Gao, Yuan,et al."Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata".FITOTERAPIA 107(2015):44-48. |
入库方式： OAI收割
来源：昆明植物研究所
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