Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae
文献类型：期刊论文
| 作者 | Lee,Ik-Soo; Jung,Seung-Hyun; Lee,Yun Mi; Choi,So-Jin; Sun,Hang ; Kim,Jin Sook
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 78期号:9页码:2249-2254 |
| 英文摘要 | Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 mu M. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | DIABETIC COMPLICATIONS ; FLAVONOIDS ; GLYCOSIDES ; BIPHENYL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362056200013 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25180]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 推荐引用方式 GB/T 7714 | Lee,Ik-Soo,Jung,Seung-Hyun,Lee,Yun Mi,et al. Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(9):2249-2254. |
| APA | Lee,Ik-Soo,Jung,Seung-Hyun,Lee,Yun Mi,Choi,So-Jin,Sun,Hang,&Kim,Jin Sook.(2015).Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae.JOURNAL OF NATURAL PRODUCTS,78(9),2249-2254. |
| MLA | Lee,Ik-Soo,et al."Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae".JOURNAL OF NATURAL PRODUCTS 78.9(2015):2249-2254. |
入库方式： OAI收割
来源：昆明植物研究所
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