Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives
文献类型：期刊论文
| 作者 | Wu, Chongyang1; Li, Guofeng1; Sun, Wangsheng1; Zhang, Ming1; Hong, Liang1; Wang R(王锐)1,2 |
| 刊名 | Organic Letters
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:7页码:1960-1963 |
| ISSN号 | 1523-7060 |
| 英文摘要 | A new practical organocatalytic asymmetric protocol for the introduction of a monofluoroalkyl group into the oxindole framework has been successfully developed. Excellent diastereoselectivities (>20:1 dr) and enantioselectivities (93-99% cc) of the products were obtained with a wide range of pre-electrophiles (3-bromooxindoles) and prenucleophiles (alpha-fluorinated beta-keto gem-diols). The obtained products themselves and their derivatives may significantly benefit drug discovery. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | the NSFC (91213302;21272102;21202071);the Fundamental Research Funds for the Central Universities (lzujbky-2013-ct06;lzujbky-2013-77) |
| 语种 | 英语 |
| WOS记录号 | WOS:000334016600033 |
| 源URL | [http://210.77.64.217/handle/362003/19254]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | 1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Chongyang,Li, Guofeng,Sun, Wangsheng,et al. Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives[J]. Organic Letters,2014,16(7):1960-1963. |
| APA | Wu, Chongyang,Li, Guofeng,Sun, Wangsheng,Zhang, Ming,Hong, Liang,&Wang R.(2014).Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives.Organic Letters,16(7),1960-1963. |
| MLA | Wu, Chongyang,et al."Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives".Organic Letters 16.7(2014):1960-1963. |
入库方式： OAI收割
来源：兰州化学物理研究所
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