Unnatural Chiral N-tert-Butanesulfinyl alpha-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives
文献类型：期刊论文
| 作者 | Lin, Li1; Fu, Xu1; Ma, Xiaojuan1; Zhang, Jinlong1; Wang R(王锐)1,2 |
| 刊名 | SYNLETT
 |
| 出版日期 | 2012 |
| 期号 | 17页码:2559-2563 |
| 关键词 | unnatural alpha-amino acids peptides regioselectivity asymmetric synthesis chiral auxiliaries |
| ISSN号 | 0936-5214 |
| 通讯作者 | 王锐 |
| 英文摘要 | This work provides a general approach to unnatural chiral N-tert-butanesulfinyl alpha-amino acid synthesis with high yields and excellent diastereoselectivities (dr up to 98: 2). The asymmetric addition of organometallic reagents to N-tert-butylsulfinyl imino acetate proceeded with excellent diastereo- and regioselectivities even on a 10 mmol scale. The sterically constrained 2',6'-dimethyltyrosine (Dmt) derivative was also readily prepared from commercially available and inexpensive starting materials through simple steps. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | NSFC (nos. 21002043;20932003;90813012);the Key National S & T Program 'Major New Drug Development' of the Ministry of Science and Technology (2012ZX09504001-003) |
| 语种 | 英语 |
| WOS记录号 | WOS:000309806400026 |
| 源URL | [http://210.77.64.217/handle/362003/19338]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | 1.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, P. R. of China 2.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China |
| 推荐引用方式 GB/T 7714 | Lin, Li,Fu, Xu,Ma, Xiaojuan,et al. Unnatural Chiral N-tert-Butanesulfinyl alpha-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives[J]. SYNLETT,2012(17):2559-2563. |
| APA | Lin, Li,Fu, Xu,Ma, Xiaojuan,Zhang, Jinlong,&Wang R.(2012).Unnatural Chiral N-tert-Butanesulfinyl alpha-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives.SYNLETT(17),2559-2563. |
| MLA | Lin, Li,et al."Unnatural Chiral N-tert-Butanesulfinyl alpha-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives".SYNLETT .17(2012):2559-2563. |
入库方式： OAI收割
来源：兰州化学物理研究所
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