Preparation and characterization of magnetic alginate-chitosan hydrogel beads loaded matrine
文献类型：期刊论文
| 作者 | Zhang, Ling-Ling1; Li, Ping1,2; Li, Yu-Min1,2; Wang AQ(王爱勤)3
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| 刊名 | Drug Development and Industrial Pharmacy
 |
| 出版日期 | 2012 |
| 卷号 | 38期号:7页码:872-882 |
| 关键词 | Matrine chitosan pH sensitive magnetic hydrogel beads |
| ISSN号 | 0363-9045 |
| 通讯作者 | Li, Ping |
| 英文摘要 | The aim of this study was to use alginate-chitosan (Alg-CS) hydrogel beads for developing an oral water-soluble drug delivery system, occupying pH-sensitive property and superparamagnetic. Matrine as a model drug was loaded in Alg-CS hydrogel beads to study the release character of the delivery system. The amount of matrine released from the beads was relatively low in pH 2.5 over 8 h (34.90%), but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 6.8) within 8 h. The results demonstrated that Alg-CS hydrogel beads possess unique pH-dependent swelling behaviors. In addition, the magnetic beads were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffractometry and vibrating-sample magnetometry. Magnetometer measurements data suggested that Alg-CS beads also had superparamagnetic property as well as fast magnetic response. It can be expected that the beads can deliver and release encapsulated anticancer agent at the tumor by the weak magnetic field, and hence could be potential candidates as an orally administered drug delivery system. |
| 学科主题 | 环境材料与生态化学 |
| 收录类别 | SCI |
| 资助信息 | the Pedestal Plan Fund for Science and Technology of Gansu province, China (Grant No. 0708NKCA129) |
| 语种 | 英语 |
| WOS记录号 | WOS:000304357900012 |
| 源URL | [http://210.77.64.217/handle/362003/19337]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 作者单位 | 1.Lanzhou University Second Hospital, Lanzhou, China 2.Key Laboratory of Digestive System Tumors, Gansu Province, China 3.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China |
| 推荐引用方式 GB/T 7714 | Zhang, Ling-Ling,Li, Ping,Li, Yu-Min,et al. Preparation and characterization of magnetic alginate-chitosan hydrogel beads loaded matrine[J]. Drug Development and Industrial Pharmacy,2012,38(7):872-882. |
| APA | Zhang, Ling-Ling,Li, Ping,Li, Yu-Min,&Wang AQ.(2012).Preparation and characterization of magnetic alginate-chitosan hydrogel beads loaded matrine.Drug Development and Industrial Pharmacy,38(7),872-882. |
| MLA | Zhang, Ling-Ling,et al."Preparation and characterization of magnetic alginate-chitosan hydrogel beads loaded matrine".Drug Development and Industrial Pharmacy 38.7(2012):872-882. |
入库方式： OAI收割
来源：兰州化学物理研究所
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