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Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis
文献类型：期刊论文
| 作者 | Zhou, JJ; Cheng, C; Qiu, ZL; Zhou, WH; Cheng, GQ |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:6页码:763-768 |
| 关键词 | INJURY IN-VIVO SYSTEMIC INFLAMMATION MICROGLIAL RESPONSE ACTIVATED MICROGLIA CX43 HEMICHANNELS DEVELOPING BRAIN PRETERM INFANTS INFECTION CHANNELS |
| 通讯作者 | Cheng, GQ (reprint author), Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China.,gqchengcm@sina.com |
| 英文摘要 | Neonatal sepsis is common in neonatal intensive care units, often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43 (Cx43) in the brain decreases when stimulated by neuro-inflammatory drugs such as lipopolysaccharide (LPS). Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic LPS injection. Moreover, microglial activation was inhibited in mice with partial deletion of Cx43. These results showed that Cx43 in astrocytes plays a critical role in neuro-inflammatory responses. This work provides a potential therapeutic target for inhibiting neuro-inflammatory responses in neonatal sepsis. |
| WOS标题词 | Neurosciences & Neurology |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365763300013 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3924]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhou, JJ,Cheng, C,Qiu, ZL,et al. Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis[J]. NEUROSCIENCE BULLETIN,2015,31(6):763-768. |
| APA | Zhou, JJ,Cheng, C,Qiu, ZL,Zhou, WH,&Cheng, GQ.(2015).Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis.NEUROSCIENCE BULLETIN,31(6),763-768. |
| MLA | Zhou, JJ,et al."Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis".NEUROSCIENCE BULLETIN 31.6(2015):763-768. |
入库方式： OAI收割
来源：上海神经科学研究所
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