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ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models
文献类型：期刊论文
| 作者 | Yue, W; Li, YY; Zhang, T; Jiang, M; Qian, Y; Zhang, M; Sheng, NY; Feng, S; Tang, K; Yu, X |
| 刊名 | STEM CELL REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:5页码:776-790 |
| 关键词 | EMBRYONIC STEM-CELLS SONIC HEDGEHOG PARKINSONS-DISEASE TRANSGENIC MICE MEMORY DEFICITS AMYLOID-BETA TRANSPLANTATION DISORDERS BRAIN RATS |
| 通讯作者 | Yue, CM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,cmyue@sibcb.ac.cn ; njing@sibcb.ac.cn |
| 英文摘要 | Degeneration of basal forebrain cholinergic neurons (BFCNs) is associated with cognitive impairments of Alzheimer's disease (AD), implying that BFCNs hold potentials in exploring stem cell-based replacement therapy for AD. However, studies on derivation of BFCNs from embryonic stem cells (ESCs) are limited, and the application of ESC-derived BFCNs remains to be determined. Here, we report on differentiation approaches for directing both mouse and human ESCs into mature BFCNs. These ESC-derived BFCNs exhibit features similar to those of their in vivo counterparts and acquire appropriate functional properties. After transplantation into the basal forebrain of AD model mice, ESC-derived BFCN progenitors predominantly differentiate into mature cholinergic neurons that functionally integrate into the endogenous basal forebrain cholinergic projection system. The AD mice grafted with mouse or human BFCNs exhibit improvements in learning and memory performances. Our findings suggest a promising perspective of ESC-derived BFCNs in the development of stem cell-based therapies for treatment of AD. |
| WOS标题词 | Cell Biology |
| 学科主题 | Cell & Tissue Engineering; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364991000010 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3925]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yue, W,Li, YY,Zhang, T,et al. ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models[J]. STEM CELL REPORTS,2015,5(5):776-790. |
| APA | Yue, W.,Li, YY.,Zhang, T.,Jiang, M.,Qian, Y.,...&Jing, NH.(2015).ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models.STEM CELL REPORTS,5(5),776-790. |
| MLA | Yue, W,et al."ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models".STEM CELL REPORTS 5.5(2015):776-790. |
入库方式： OAI收割
来源：上海神经科学研究所
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