热门
Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M
文献类型：期刊论文
| 作者 | Miller, M; Beppu, A; Rosenthal, P; Pham, A; Das, S; Karta, M; Song, DJ; Vuong, C; Doherty, T; Croft, M |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 195期号:8页码:3546-3556 |
| 关键词 | FOLLISTATIN-LIKE 1 PULMONARY-FIBROSIS MOUSE MODEL MICE EXPRESSION LUNG INFLAMMATION PROTEIN-1 ARTHRITIS INHIBITION |
| 通讯作者 | Broide, DH (reprint author), Univ Calif San Diego, Dept Med, Biomed Sci Bldg,Room 5090,9500 Gilman Dr, La Jolla, CA 92093 USA.,dbroide@ucsd.edu |
| 英文摘要 | Chronic asthma is associated with airway remodeling and decline in lung function. In this article, we show that follistatin-like 1 (Fstl1), a mediator not previously associated with asthma, is highly expressed by macrophages in the lungs of humans with severe asthma. Chronic allergen-challenged Lys-Cre(tg) /Fstl1(Delta/Delta) mice in whom Fstl1 is inactivated in macrophages/myeloid cells had significantly reduced airway remodeling and reduced levels of oncostatin M (OSM), a cytokine previously not known to be regulated by Fstl1. The importance of the Fstl1 induction of OSM to airway remodeling was demonstrated in murine studies in which administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation, and airway hyperresponsiveness, all cardinal features of asthma. Overall, these studies demonstrate that the Fstl1/OSM pathway may be a novel pathway to inhibit airway remodeling in severe human asthma. |
| WOS标题词 | Immunology |
| 学科主题 | Immunology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362968100010 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3929]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Miller, M,Beppu, A,Rosenthal, P,et al. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M[J]. JOURNAL OF IMMUNOLOGY,2015,195(8):3546-3556. |
| APA | Miller, M.,Beppu, A.,Rosenthal, P.,Pham, A.,Das, S.,...&Broide, DH.(2015).Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M.JOURNAL OF IMMUNOLOGY,195(8),3546-3556. |
| MLA | Miller, M,et al."Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M".JOURNAL OF IMMUNOLOGY 195.8(2015):3546-3556. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。