热门
Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles
文献类型：期刊论文
| 作者 | Liu, H; Wu, QF; Li, JY; Liu, XJ; Li, KC; Zhong, YQ; Wu, D; Wang, Q; Lu, YJ; Bao, L |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:5页码:466-475 |
| 关键词 | SUBSTANTIA-GELATINOSA NEURONS DELTA-OPIOID RECEPTOR DORSAL-ROOT GANGLION RAT SPINAL-CORD AFFERENT GLUTAMATERGIC TRANSMISSION NEUROPATHIC PAIN SENSORY NEURONS INFLAMMATORY PAIN UP-REGULATION IN-VITRO |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | Fibroblast growth factor (FGF) 7, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. However, its functions in the nervous system are largely unknown. The present study showed that FGF7 was a neuromodulator localized in the large dense-core vesicles (LDCVs) in nociceptive neurons. FGF7 was mainly expressed in small-diameter neurons of the dorsal root ganglion and could be transported to the dorsal spinal cord. Interestingly, FGF7 was mostly stored in LDCVs that did not contain neuropeptide substance P. Electrophysiological recordings in the spinal cord slice showed that buffer-applied FGF7 increased the amplitude of excitatory post-synaptic current evoked by stimulating the sensory afferent fibers. Behavior tests showed that intra-thecally applied FGF7 potentiated the formalin-induced acute nociceptive response. Moreover, both acute and inflammatory nociceptive responses were significantly reduced in Fgf7-deficient mice. These results suggest that FGF7 exerts an excitatory modulation of nociceptive afferent transmission. |
| WOS标题词 | Cell Biology |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000363201800008 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3930]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, H,Wu, QF,Li, JY,et al. Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(5):466-475. |
| APA | Liu, H.,Wu, QF.,Li, JY.,Liu, XJ.,Li, KC.,...&Zhang, X.(2015).Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles.JOURNAL OF MOLECULAR CELL BIOLOGY,7(5),466-475. |
| MLA | Liu, H,et al."Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles".JOURNAL OF MOLECULAR CELL BIOLOGY 7.5(2015):466-475. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。