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Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes
文献类型：期刊论文
| 作者 | Bian, WJ; Miao, WY; He, SJ; Qiu, Z; Yu, X |
| 刊名 | CELL
 |
| 出版日期 | 2015 |
| 卷号 | 162期号:4页码:808-822 |
| 关键词 | LONG-TERM POTENTIATION DENDRITIC SPINES SYNAPTIC PLASTICITY N-CADHERIN CEREBRAL-CORTEX IN-VIVO NEUROPSYCHIATRIC DISORDERS HIPPOCAMPAL DENDRITES DIVERSE REGIONS ADULT NEOCORTEX |
| 通讯作者 | Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China.,yuxiang@ion.ac.cn |
| 英文摘要 | Dendritic spines are postsynaptic compartments of excitatory synapses that undergo dynamic changes during development, including rapid spinogenesis in early postnatal life and significant pruning during adolescence. Spine pruning defects have been implicated in developmental neurological disorders such as autism, yet much remains to be uncovered regarding its molecular mechanism. Here, we show that spine pruning and maturation in the mouse somatosensory cortex are coordinated via the cadherin/catenin cell adhesion complex and bidrectionally regulated by sensory experience. We further demonstrate that locally enhancing cadherin/catenin-dependent adhesion or photo-stimulating a contacting channelrhodopsin-expressing axon stabilized the manipulated spine and eliminated its neighbors, an effect requiring cadherin/catenin-dependent adhesion. Importantly, we show that differential cadherin/catenin-dependent adhesion between neighboring spines biased spine fate in vivo. These results suggest that activity-induced inter-spine competition for beta-catenin provides specificity for concurrent spine maturation and elimination and thus is critical for the molecular control of spine pruning during neural circuit refinement. |
| WOS标题词 | Biochemistry & Molecular Biology ; Cell Biology |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359741400014 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3935]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Bian, WJ,Miao, WY,He, SJ,et al. Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes[J]. CELL,2015,162(4):808-822. |
| APA | Bian, WJ,Miao, WY,He, SJ,Qiu, Z,&Yu, X.(2015).Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes.CELL,162(4),808-822. |
| MLA | Bian, WJ,et al."Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes".CELL 162.4(2015):808-822. |
入库方式： OAI收割
来源：上海神经科学研究所
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