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Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking
文献类型：期刊论文
| 作者 | Zhu, SY; Zhao, CJ; Wu, YY; Yang, QQ; Shao, AY; Wang, TP; Wu, JF; Yin, YQ; Li, YD; Hou, JC |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2015 |
| 卷号 | 18期号:8页码:1084-1084 |
| 关键词 | DOPAMINE TRANSPORTER TRAFFICKING NUCLEOTIDE EXCHANGE FACTORS VAV FAMILY PLASMA-MEMBRANE KINASE MICE PHOSPHORYLATION RECEPTOR NEURONS GROWTH |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Ctr Excellence Brain Sci, Shanghai Inst Biol Sci, Inst Neurosci,State Key Lab Neurosci, Shanghai, Peoples R China.,jwzhou@ion.ac.cn |
| 英文摘要 | Dopamine (DA) homeostasis is essential for a variety of brain activities. Dopamine transporter (DAT)-mediated DA reuptake is one of the most critical mechanisms for normal DA homeostasis. However, the molecular mechanisms underlying the regulation of DAT activity in the brain remain poorly understood. Here we show that the Rho-family guanine nucleotide exchange factor protein Vav2 is required for DAT cell surface expression and transporter activity modulated by glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor Ret. Mice deficient in either Vav2 or Ret displayed elevated DAT activity, which was accompanied by an increase in intracellular DA selectively in the nucleus accumbens. Vav2(-/-) mice exposed to cocaine showed reduced DAT activity and diminished behavioral cocaine response. Our data demonstrate that Vav2 is a determinant of DAT trafficking in vivo and contributes to the maintenance of DA homeostasis in limbic DA neuron terminals. |
| WOS标题词 | Neurosciences & Neurology |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358605400008 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3939]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhu, SY,Zhao, CJ,Wu, YY,et al. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking[J]. NATURE NEUROSCIENCE,2015,18(8):1084-1084. |
| APA | Zhu, SY.,Zhao, CJ.,Wu, YY.,Yang, QQ.,Shao, AY.,...&Zhou, JW.(2015).Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.NATURE NEUROSCIENCE,18(8),1084-1084. |
| MLA | Zhu, SY,et al."Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking".NATURE NEUROSCIENCE 18.8(2015):1084-1084. |
入库方式： OAI收割
来源：上海神经科学研究所
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