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Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia
文献类型：期刊论文
| 作者 | Li, Q; Zhai, LY; Jiang, QY; Qin, W; Li, QJ; Yin, XH; Guo, MX |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 597期号:1页码:712-712 |
| 关键词 | VOXEL-BASED MORPHOMETRY ABNORMAL VISUAL-CORTEX DIFFUSION MRI OPTIC RADIATION HUMAN BRAIN TRACTOGRAPHY DISSECTION FASCICULUS INTEGRITY SHAPE |
| 通讯作者 | Guo, MX (reprint author), Tianjin Med Univ, Sch Med Imaging, 1 Guangdong Rd, Tianjin 300203, Peoples R China.,guomx11@163.com |
| 英文摘要 | Amblyopia is a neurological disorder of vision that follows abnormal binocular interaction or visual deprivation during early life. Previous studies have reported multiple functional or structural cortical alterations. Although white matter was also studied, it still cannot be clarified clearly which fasciculus was affected by amblyopia. In the present study, tract-based spatial statistics analysis was applied to diffusion tensor imaging (DTI) to investigate potential diffusion changes of neural tracts in anisometropic amblyopia. Fractional anisotropy (FA) value was calculated and compared between 20 amblyopic children and 18 healthy age-matched controls. In contrast to the controls, significant decreases in FA values were found in right optic radiation (OR), left inferior longitudinal fasciculus/inferior fronto-occipital fasciculus (ILF/IFO) and right superior longitudinal fasciculus (SLF) in the amblyopia. Furthermore, FA values of these identified tracts showed positive correlation with visual acuity. It can be inferred that abnormal visual input not only hinders OR from well developed, but also impairs fasciculi associated with dorsal and ventral visual pathways, which may be responsible for the amblyopic deficiency in object discrimination and stereopsis. Increased FA was detected in right posterior part of corpus callosum (CC) with a medium effect size, which may be due to compensation effect. DTI with subsequent measurement of FA is a useful tool for investigating neuronal tract involvement in amblyopia. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Neurosciences & Neurology |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356186100002 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3944]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Q,Zhai, LY,Jiang, QY,et al. Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia[J]. NEUROSCIENCE LETTERS,2015,597(1):712-712. |
| APA | Li, Q.,Zhai, LY.,Jiang, QY.,Qin, W.,Li, QJ.,...&Guo, MX.(2015).Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia.NEUROSCIENCE LETTERS,597(1),712-712. |
| MLA | Li, Q,et al."Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia".NEUROSCIENCE LETTERS 597.1(2015):712-712. |
入库方式： OAI收割
来源：上海神经科学研究所
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