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Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons
文献类型：期刊论文
| 作者 | Jiang, J; Zhang, ZH; Yuan, XB; Poo, MM |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 209期号:5页码:759-774 |
| 关键词 | FOCAL ADHESION KINASE COLLECTIVE CELL-MIGRATION MYOSIN-II MEMBRANE TENSION INTEGRIN ACTIVATION NEUROTROPHIC FACTOR ACTIN DYNAMICS AXON GUIDANCE GROWTH CONE MICROTUBULES |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China.,mpoo@ion.ac.cn |
| 英文摘要 | Traction force against the substrate is required for neuronal migration, but how it is generated and regulated remains controversial. Using traction force microscopy, we showed in cultured granule cells the coexistence of three distinct contraction centers (CCs) that are located at the distal and proximal regions of the leading process as well as at the trailing process, regions exhibiting high-level myosin-II activities. The CC activities depended on myosin-II, actin filaments, and microtubules, as well as substrate adhesion, and exhibited apparently independent fluctuation. The difference of strain energies associated with CC activities between leading versus trailing processes tightly correlated with the displacement of the soma at any given time. Application of brain-derived neurotrophic factor (BDNF) and Slit2, factors known to guide neuronal migration, at the leading process altered CC activities by regulating the small GTPases Cdc42 and RhoA, respectively, leading to forward and rearward soma translocation. These results delineate the multiple origins and spatiotemporal dynamics of the traction force underlying neuronal migration. |
| WOS标题词 | Cell Biology |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355938200010 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3945]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Jiang, J,Zhang, ZH,Yuan, XB,et al. Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons[J]. JOURNAL OF CELL BIOLOGY,2015,209(5):759-774. |
| APA | Jiang, J,Zhang, ZH,Yuan, XB,&Poo, MM.(2015).Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons.JOURNAL OF CELL BIOLOGY,209(5),759-774. |
| MLA | Jiang, J,et al."Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons".JOURNAL OF CELL BIOLOGY 209.5(2015):759-774. |
入库方式： OAI收割
来源：上海神经科学研究所
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