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Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity
文献类型：期刊论文
| 作者 | Chen, Y; Wu, R; Chen, HZ; Xiao, Q; Wang, WJ; He, JP; Li, XX; Yu, XW; Li, L; Wang, P |
| 刊名 | DIABETES
 |
| 出版日期 | 2015 |
| 卷号 | 64期号:6页码:2069-2081 |
| 关键词 | ENERGY-BALANCE GLUCOSE-METABOLISM SIGNAL TRANSDUCER SKELETAL-MUSCLE FOOD-INTAKE ORPHAN PROOPIOMELANOCORTIN EXPRESSION RESISTANCE HORMONE |
| 通讯作者 | Wu, Q (reprint author), Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen, Fujian Province, Peoples R China.,giaow@xmu.edu.cn |
| 英文摘要 | Leptin, an anorexigenic hormone in the hypothalamus, suppresses food intake and increases energy expenditure. Failure to respond to leptin will lead to obesity. Here, we discovered that nuclear receptor Nur77 expression is lower in the hypothalamus of obese mice compared with normal mice. Injection of leptin results in significant reduction in body weight in wild-type mice but not in Nur77 knockout (KO) littermates or mice with specific Nur77 knockdown in the hypothalamus. Hypothalamic Nur77 not only participates in leptin central control of food intake but also expands leptin's reach to liver and adipose tissues to regulate lipid metabolism. Nur77 facilitates signal transducer and activator of transcription 3 (STAT3) acetylation by recruiting acetylase p300 and disassociating deacetylase histone deacetylase 1 (HDAC1) to enhance the transcriptional activity of STAT3 and consequently modulates the expression of downstream gene Pomc in the hypothalamus. Nur77 deficiency compromises response to leptin in mice fed a high-fat diet. Severe leptin resistance in Nur77 KO mice with increased appetite, lower energy expenditure, and hyperleptinemia contributes to aging-induced obesity. Our study opens a new avenue for regulating metabolism with Nur77 as the positive modulator in the leptin-driven antiobesity in the hypothalamus. |
| WOS标题词 | Endocrinology & Metabolism |
| 学科主题 | Endocrinology & Metabolism |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355370900022 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3947]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, Y,Wu, R,Chen, HZ,et al. Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity[J]. DIABETES,2015,64(6):2069-2081. |
| APA | Chen, Y.,Wu, R.,Chen, HZ.,Xiao, Q.,Wang, WJ.,...&Wu, Q.(2015).Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity.DIABETES,64(6),2069-2081. |
| MLA | Chen, Y,et al."Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity".DIABETES 64.6(2015):2069-2081. |
入库方式： OAI收割
来源：上海神经科学研究所
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