Aging accelerates memory extinction and impairs memory restoration in Drosophila
文献类型：期刊论文
| 作者 | Chen, NN; Guo, AK; Li, Y |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 460期号:4页码:944-948 |
| 关键词 | ANESTHESIA-RESISTANT MEMORY CONSOLIDATED MEMORY OLFACTORY MEMORY FEAR AGE PROTEIN REINSTATEMENT RECOGNITION CONTEXT PHASES |
| 通讯作者 | Guo, AK (reprint author), Chinese Acad Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China.,akguo@ion.ac.cn ; liyan@ibp.ac.cn |
| 英文摘要 | Age-related memory impairment (AMI) is a phenomenon observed from invertebrates to human. Memory extinction is proposed to be an active inhibitory modification of memory, however, whether extinction is affected in aging animals remains to be elucidated. Employing a modified paradigm for studying memory extinction in fruit flies, we found that only the stable, but not the labile memory component was suppressed by extinction, thus effectively resulting in higher memory loss in aging flies. Strikingly, young flies were able to fully restore the stable memory component 3 h post extinction, while aging flies failed to do so. In conclusion, our findings reveal that both accelerated extinction and impaired restoration contribute to memory impairment in aging animals. (C) 2015 Elsevier Inc. All rights reserved. |
| WOS标题词 | Biochemistry & Molecular Biology ; Biophysics |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356980900009 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3948]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, NN,Guo, AK,Li, Y. Aging accelerates memory extinction and impairs memory restoration in Drosophila[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,460(4):944-948. |
| APA | Chen, NN,Guo, AK,&Li, Y.(2015).Aging accelerates memory extinction and impairs memory restoration in Drosophila.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(4),944-948. |
| MLA | Chen, NN,et al."Aging accelerates memory extinction and impairs memory restoration in Drosophila".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460.4(2015):944-948. |
入库方式： OAI收割
来源：上海神经科学研究所
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