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Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury
文献类型：期刊论文
| 作者 | Ma, SM; Chen, LX; Lin, YF; Yan, H; Lv, JW; Xiong, M; Li, J; Cheng, GQ; Yang, Y; Qiu, ZL |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:4页码:e0123585-e0123585 |
| 关键词 | NEONATAL BRAIN-INJURY ADULT NEUROGENESIS RAT BRAIN REGENERATION EXPRESSION MIGRATION STROKE MODEL ISCHEMIA/HYPOXIA ENCEPHALOPATHY |
| 通讯作者 | Zhou, WH (reprint author), Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 200433, Peoples R China.,zwhchfu@126.com |
| 英文摘要 | Neural stem cell (NSC) proliferation and differentiation are required to replace neurons damaged or lost after hypoxic-ischemic events and recover brain function. Periostin (POSTN), a novel matricellular protein, plays pivotal roles in the survival, migration, and regeneration of various cell types, but its function in NSCs of neonatal rodent brain is still unknown. The purpose of this study was to investigate the role of POSTN in NSCs following hypoxia-ischemia (HI). We found that POSTN mRNA levels significantly increased in differentiating NSCs. The proliferation and differentiation of NSCs in the hippocampus is compromised in POSTN knockout mice. Moreover, NSC proliferation and differentiation into neurons and astrocytes significantly increased in cultured NSCs treated with recombinant POSTN. Consistently, injection of POSTN into neonatal hypoxic-ischemic rat brains stimulated NSC proliferation and differentiation in the subventricular and subgranular zones after 7 and 14 days of brain injury. Lastly, POSTN treatment significantly improved the spatial learning deficits of rats subjected to HI. These results suggest that POSTN significantly enhances NSC proliferation and differentiation after HI, and provides new insights into therapeutic strategies for the treatment of hypoxic-ischemic encephalopathy. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353211700045 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3951]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ma, SM,Chen, LX,Lin, YF,et al. Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury[J]. PLOS ONE,2015,10(4):e0123585-e0123585. |
| APA | Ma, SM.,Chen, LX.,Lin, YF.,Yan, H.,Lv, JW.,...&Zhou, WH.(2015).Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury.PLOS ONE,10(4),e0123585-e0123585. |
| MLA | Ma, SM,et al."Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury".PLOS ONE 10.4(2015):e0123585-e0123585. |
入库方式： OAI收割
来源：上海神经科学研究所
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