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Control of response reliability by parvalbumin-expressing interneurons in visual cortex
文献类型：期刊论文
| 作者 | Zhu, YJ; Qiao, WH; Liu, KF; Zhong, HY; Yao, HS |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:1页码:6802-6802 |
| 关键词 | CAT STRIATE CORTEX NETWORKS IN-VIVO CORTICAL ACTIVITY AUDITORY-CORTEX FEEDFORWARD INHIBITION GABAERGIC INTERNEURONS SPATIAL INTEGRATION RECEPTIVE-FIELDS PYRAMIDAL CELLS NATURAL STIMULI |
| 通讯作者 | Yao, HS (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,haishanyao@ion.ac.cn |
| 英文摘要 | The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution of specific types of inhibitory neurons is not well understood. Here we demonstrate that optogenetic suppression of parvalbumin (PV)-but not somatostatin (SOM)-expressing interneurons reduces response reliability in the primary visual cortex of anaesthetized and awake mice. PV suppression leads to increases in the low firing rates and decreases in the high firing rates of cortical neurons, resulting in an overall reduction of the signal-to-noise ratio (SNR). In contrast, SOM suppression generally increases the overall firing rate for most neurons, without affecting the SNR. Further analysis reveals that PV, but not SOM, suppression impairs neural discrimination of natural stimuli. Together, these results reveal a critical role for PV interneurons in the formation of reliable visual cortical representations of natural stimuli. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353702500042 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/3954]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhu, YJ,Qiao, WH,Liu, KF,et al. Control of response reliability by parvalbumin-expressing interneurons in visual cortex[J]. NATURE COMMUNICATIONS,2015,6(1):6802-6802. |
| APA | Zhu, YJ,Qiao, WH,Liu, KF,Zhong, HY,&Yao, HS.(2015).Control of response reliability by parvalbumin-expressing interneurons in visual cortex.NATURE COMMUNICATIONS,6(1),6802-6802. |
| MLA | Zhu, YJ,et al."Control of response reliability by parvalbumin-expressing interneurons in visual cortex".NATURE COMMUNICATIONS 6.1(2015):6802-6802. |
入库方式： OAI收割
来源：上海神经科学研究所
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