Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind
文献类型：期刊论文
| 作者 | Jiang, Aili1,2; Tian, Jing1,2; Li, Rui1,2 ; Liu, Yong3; Jiang, Tianzi3; Qin, Wen1,2; Yu, Chunshui1,2
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| 刊名 | NEURAL PLASTICITY
 |
| 出版日期 | 2015 |
| 英文摘要 | Visual deprivation can induce alterations of regional spontaneous brain activity (RSBA). However, the effects of onset age of blindness on the RSBA and the association between the alterations of RSBA and brain structure are still unclear in the blind. In this study, we performed resting-state functional and structural magnetic resonance imaging on 50 sighted controls and 91 blind subjects (20 congenitally blind, 27 early blind, and 44 late blind individuals). Compared with the sighted control, we identified increased RSBA in the blind in primary and high-level visual areas and decreased RSBA in brain regions which are ascribed to sensorimotor and salience networks. In contrast, blind subjects exhibited significantly decreased gray matter volume (GMV) in the visual areas, while they exhibited significantly increased GMV in the sensorimotor areas. Moreover, the onset age of blindness was negatively correlated with the GMV of visual areas in blind subjects, whereas it exerted complex influences on the RSBA. Finally, significant negative correlations were shown between RSBA and GMV values. Our results demonstrated system-dependent, inverse alterations in RSBA and GMV after visual deprivation. Furthermore, the onset age of blindness has different effects on the reorganizations in RSBA and GMV. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | VISUAL-CORTEX ; OCCIPITAL CORTEX ; CONGENITAL BLINDNESS ; SENSITIVE PERIOD ; NEURAL ACTIVITY ; WHITE-MATTER ; CONNECTIVITY ; HUMANS ; FMRI ; INDIVIDUALS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364138400001 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10502]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Aili,Tian, Jing,Li, Rui,et al. Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind[J]. NEURAL PLASTICITY,2015. |
| APA | Jiang, Aili.,Tian, Jing.,Li, Rui.,Liu, Yong.,Jiang, Tianzi.,...&Yu, Chunshui.(2015).Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind.NEURAL PLASTICITY. |
| MLA | Jiang, Aili,et al."Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind".NEURAL PLASTICITY (2015). |
入库方式： OAI收割
来源：自动化研究所
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