The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation
文献类型：期刊论文
| 作者 | Jiang, Guangyao1; Yin, Xuntao1,2; Li, Chuanming1; Li, Lei3 ; Zhao, Lu2; Evans, Alan C.2; Jiang, Tianzi4; Wu, Jixiang3; Wang, Jian1
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| 刊名 | NEURAL PLASTICITY
 |
| 出版日期 | 2015 |
| 英文摘要 | Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC). Smaller clusters were also noted in the visual-to-motor regions. In addition, the amputees also exhibited a decreased FA in the right superior corona radiata and WM regions underlying the right temporal lobe and left PMC. Fiber tractography from these WM regions showed microstructural changes in the commissural fibers connecting the bilateral premotor cortices, compatible with the hypothesis that amputation can lead to a change in interhemispheric interactions. Finally, the lower limb amputees also displayed significant FA reduction in the right inferior frontooccipital fasciculus, which is negatively correlated with the time since amputation. In conclusion, our findings indicate that the amputation of lower limb could induce changes in the cortical representation of the missing limb and the underlying WM connections. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | CORTICAL REORGANIZATION ; PREMOTOR CORTEX ; PARIETAL-CORTEX ; MOTOR CORTEX ; PAIN ; ATTENTION ; SELECTION ; AMPUTEES ; INJURY ; IMAGES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364719700001 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10505]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Third Mil Med Univ, Dept Radiol, Southwest Hosp, Chongqing 400038, Peoples R China 2.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada 3.Third Mil Med Univ, Dept Rehabil, Southwest Hosp, Chongqing 400038, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Guangyao,Yin, Xuntao,Li, Chuanming,et al. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation[J]. NEURAL PLASTICITY,2015. |
| APA | Jiang, Guangyao.,Yin, Xuntao.,Li, Chuanming.,Li, Lei.,Zhao, Lu.,...&Wang, Jian.(2015).The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation.NEURAL PLASTICITY. |
| MLA | Jiang, Guangyao,et al."The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation".NEURAL PLASTICITY (2015). |
入库方式： OAI收割
来源：自动化研究所
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