RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory
文献类型：期刊论文
| 作者 | Li, Jin1,2 ; Liu, Bing1,2; Chen, Chuansheng3; Cui, Yue1,2; Shang, Liqing4; Zhang, Yun4; Wang, Chao4; Zhang, Xiaolong1,2; He, Qinghua5; Zhang, Wen4
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| 刊名 | HUMAN BRAIN MAPPING
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| 出版日期 | 2015-11-01 |
| 卷号 | 36期号:11页码:4372-4382 |
| 关键词 | Ras-related protein Rab-2A (RAB2A) cortical thickness functional connectivity working memory |
| 英文摘要 | Calbindin-containing -aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex (PFC) have been found to play an important role in working memory (WM) and their malfunctions have been linked to psychiatric disorders. A recent genome-wide association and expression-SNP study indicated that the RAB2A gene was associated with the density of prefrontal calbindin-positive neurons, suggesting this gene may have a broader influence on prefrontal structure and function. Using multimodal MRI and behavioral tasks, the current study investigated the effect of RAB2A on prefrontal morphology, resting-state functional connectivity, and WM performance in a large sample of healthy Han Chinese subjects. Results showed that the RAB2A AGCAAA haplotype was associated with improved WM accuracy, increased cortical thickness in the left inferior frontal gyrus, and decreased functional connectivity between the left inferior frontal gyrus and the left dorsolateral PFC. Our findings provide consistent evidence supporting the effect of RAB2A on the structure and function of the PFC and related cognitive functions. These results should provide new insights into the neural mechanisms underlying the GABAergic genes' role in WM as well as its dysfunction. Hum Brain Mapp 36:4372-4382, 2015. (c) 2015 Wiley Periodicals, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | CORE VESICLE MATURATION ; CALCIUM-BINDING PROTEINS ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; CAENORHABDITIS-ELEGANS ; GABAERGIC NEURONS ; HUMAN BRAIN ; CORTICAL THICKNESS ; SCHIZOPHRENIA ; NETWORKS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364219500011 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10506]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA USA 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 5.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Li, Jin,Liu, Bing,Chen, Chuansheng,et al. RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory[J]. HUMAN BRAIN MAPPING,2015,36(11):4372-4382. |
| APA | Li, Jin.,Liu, Bing.,Chen, Chuansheng.,Cui, Yue.,Shang, Liqing.,...&Jiang, Tianzi.(2015).RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory.HUMAN BRAIN MAPPING,36(11),4372-4382. |
| MLA | Li, Jin,et al."RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory".HUMAN BRAIN MAPPING 36.11(2015):4372-4382. |
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来源：自动化研究所
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