Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction
文献类型：期刊论文
| 作者 | Zhao, Lu1; Guan, Min2; Zhang, Xiangsheng3; Karama, Sherif1,4; Khundrakpam, Budhachandra1; Wang, Meiyun2; Dong, Minghao5; Qin, Wei5; Tian, Jie5,6 ; Evans, Alan C.1
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| 刊名 | HUMAN BRAIN MAPPING
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| 出版日期 | 2015-11-01 |
| 卷号 | 36期号:11页码:4469-4482 |
| 关键词 | magnetic resonance imaging cortical thickness scale space search structural covariance network psychogenic erectile dysfunction |
| 英文摘要 | Functional neuroimaging studies have revealed abnormal brain dynamics of male sexual arousal (SA) in psychogenic erectile dysfunction (pED). However, the neuroanatomical correlates of pED are still unclear. In this work, we obtained cortical thickness (CTh) measurements from structural magnetic resonance images of 40 pED patients and 39 healthy control subjects. Abnormalities in CTh related to pED were explored using a scale space search based brain morphometric analysis. Organizations of brain structural covariance networks were analyzed as well. Compared with healthy men, pED patients showed significantly decreased CTh in widespread cortical regions, most of which were previously reported to show abnormal dynamics of male SA in pED, such as the medial prefrontal, orbitofrontal, cingulate, inferotemporal, and insular cortices. CTh reductions in these areas were found to be significantly correlated with male sexual functioning degradation. Moreover, pED patients showed decreased interregional CTh correlations from the right lateral orbitofrontal cortex to the right supramarginal gyrus and the left angular cortex, implying disassociations between the cognitive, motivational, and inhibitory networks of male SA in pED. This work provides structural insights on the complex phenomenon of psychogenic sexual dysfunction in men, and suggests a specific vulnerability factor, possibly as an extra organic factor, that may play an important role in pED. Hum Brain Mapp 36:4469-4482, 2015. (c) 2015 Wiley Periodicals, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | VISUAL SEXUAL STIMULI ; ANTERIOR CINGULATE CORTEX ; HUMAN CEREBRAL-CORTEX ; BRAIN ACTIVATION ; PENILE ERECTION ; HEALTHY-MEN ; HUMAN MALES ; NEUROPSYCHIATRIC DISORDERS ; INTERNATIONAL INDEX ; DISTINCT COMPONENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364219500017 |
| 公开日期 | 2016-02-26 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/10503]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada 2.Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou 450003, Henan, Peoples R China 3.Henan Prov Peoples Hosp, Dept Urol, Zhengzhou 450003, Henan, Peoples R China 4.McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada 5.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China 6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Lu,Guan, Min,Zhang, Xiangsheng,et al. Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction[J]. HUMAN BRAIN MAPPING,2015,36(11):4469-4482. |
| APA | Zhao, Lu.,Guan, Min.,Zhang, Xiangsheng.,Karama, Sherif.,Khundrakpam, Budhachandra.,...&Shi, Dapeng.(2015).Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction.HUMAN BRAIN MAPPING,36(11),4469-4482. |
| MLA | Zhao, Lu,et al."Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction".HUMAN BRAIN MAPPING 36.11(2015):4469-4482. |
入库方式： OAI收割
来源：自动化研究所
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