Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)
文献类型：期刊论文
| 作者 | Liu, Hao; Yu, Junjie; Xia, Tingting; Xiao, Yuzhong; Zhang, Qian; Liu, Bin; Guo, Yajie; Deng, Jiali; Deng, Yalan; Chen, Shanghai（陈上海） |
| 刊名 | BIOCHEMICAL JOURNAL
 |
| 出版日期 | 2014 |
| 卷号 | 464期号:2页码:281-289 |
| 关键词 | db/db mice extracellular-signal-regulated kinase 1/2 (ERK 1/2) glucose hepatocyte insulin signalling liver serum-and glucocorticoid-regulated kinase 1 (SGK 1) |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Insulin resistance is a major hallmark of metabolic syndromes, including Type 2 diabetes. Although numerous functions of SGK 1 (serum- and glucocorticoid-regulated kinase 1) have been identified, a direct effect of SGK 1 on insulin sensitivity has not been previously reported. In the present study, we generated liver-specific SGK1-knockout mice and found that these mice developed glucose intolerance and insulin resistance. We also found that insulin signalling is enhanced or impaired in Hep1-6 cells infected with adenoviruses expressing SGK1 (Ad-SGK1) or shRNA directed against the coding region of SGK1 (Ad-shSGK1) respectively. In addition, we determined that SGK1 inhibits ERK1/2 (extracellular-signal-regulated kinase 1/2) activity in liver and Ad-shERK 1/2-mediated inhibition of ERK1/2 reverses the attenuated insulin sensitivity in Ad-shSGK I mice. Finally, we found that SGK I functions are compromised under insulin-resistant conditions and overexpression of SGK I by Ad-SGK 1 significantly ameliorates insulin resistance in both glucosamine-treated HepG2 cells and livers of db/db mice, a genetic model of insulin resistance. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | PATHOGENIC T(H)17 CELLS ; EPITHELIAL-CELLS ; GLUCOSE ; EXPRESSION ; ACTIVATION ; RESISTANCE ; GENE ; HOMEOSTASIS ; METABOLISM ; MECHANISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345265000012 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/422]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Liu, Hao,Yu, Junjie,Xia, Tingting,et al. Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)[J]. BIOCHEMICAL JOURNAL,2014,464(2):281-289. |
| APA | Liu, Hao.,Yu, Junjie.,Xia, Tingting.,Xiao, Yuzhong.,Zhang, Qian.,...&Guo, Feifan.(2014).Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2).BIOCHEMICAL JOURNAL,464(2),281-289. |
| MLA | Liu, Hao,et al."Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)".BIOCHEMICAL JOURNAL 464.2(2014):281-289. |
入库方式： OAI收割
来源：上海营养与健康研究所
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