热门
A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis
文献类型：期刊论文
| 作者 | Xiao, Fei; Yu, Junjie; Liu, Bin; Guo, Yajie; Li, Kai; Deng, Jiali; Zhang, Jin; Wang, Chunxia; Chen, Shanghai（陈上海）; Du, Ying |
| 刊名 | DIABETES
 |
| 出版日期 | 2014 |
| 卷号 | 63期号:8页码:2631-2642 |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Grad Sch, Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China. |
| 英文摘要 | MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that are evolutionarily conserved and believed to play a role in controlling a variety of biological processes. The roles of miRNAs in insulin resistance and liver steatosis, however, are largely unknown. The objective of this study was to evaluate the roles of miR-130a in the regulation of insulin sensitivity and liver steatosis. In our current study, we observed that overexpression of miR-130a-3p increases insulin signaling in both HepG2 cells and primary mouse hepatocytes, and silencing of miR-130a-3p has the opposite effects. However, miR-130a-5p has no effect in the regulation of insulin signaling. Consistently, whole-body and hepatic insulin sensitivity are improved in mice injected with adenoviruses that overexpress miR-130a-3p. Furthermore, we provided evidence showing that growth factor receptor-bound protein 10 is required for miR-130a-3p-regulated insulin sensitivity. On the other hand, we observed that expression of miR-130a-3p is decreased in the livers of db/db mice and that adenovirus-mediated overexpression of miR-130a-3p reverses insulin resistance and liver steatosis, the latter of which is achieved via suppressing fatty acid synthase expression in these mice. This study identifies a novel function for hepatic miR-130a-3p in the regulation of insulin sensitivity and liver steatosis. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | GLUCOSE-METABOLISM ; LIPID-METABOLISM ; FATTY LIVER ; IN-VIVO ; MICE ; GRB10 ; IDENTIFICATION ; HYPERGLYCEMIA ; ASSOCIATION ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340262100014 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/425]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Xiao, Fei,Yu, Junjie,Liu, Bin,et al. A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis[J]. DIABETES,2014,63(8):2631-2642. |
| APA | Xiao, Fei.,Yu, Junjie.,Liu, Bin.,Guo, Yajie.,Li, Kai.,...&Guo, Feifan.(2014).A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis.DIABETES,63(8),2631-2642. |
| MLA | Xiao, Fei,et al."A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis".DIABETES 63.8(2014):2631-2642. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。