Branched chain amino acids and metabolic regulation
文献类型：期刊论文
| 作者 | Wang ChunXia; Guo FeiFan（郭非凡）
|
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2013 |
| 卷号 | 58期号:11页码:1228-1235 |
| 关键词 | branched chain amino acids amino acid sensor lipid metabolism glucose metabolism energy homeostasis obesity diabetes |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China. |
| 英文摘要 | Amino acids are fundamental nutrients required for protein synthesis. The branched chain amino acids (BCAAs) leucine, isoleueine, and valine are the most abundant of the essential amino acids. BCAAs have recently been recognized as having functions in processes other than simple nutrition. For example, metabolic diseases are characterized by higher levels of circulating BCAAs. Moreover, supplementation with or deficiency in BCAAs is closely related to the regulation of metabolic homeostasis. Indeed, leucine deprivation induces increased lipolysis and thermogenesis, which result in fat loss, as well as suppressed lipogenesis and enhanced insulin sensitivity in the liver. Accumulating evidence has indicated that several amino acid sensors, including GCN2, ATF4, mTOR, and AMPK, play pivotal roles in the regulation of lipid metabolism, glucose metabolism, and energy homeostasis. Furthermore, the hypothalamus is critical for sensing amino acid levels and mediates the metabolic adaptation of the body upon limitation of essential amino acids (EAAs) through regulating expression of the S6K1, MC4R, and CRH. In this review, we highlight recent studies investigating the cellular mechanisms linking amino acids, amino acid sensors, metabolic regulation, and metabolic diseases. Amino acid sensing and metabolic regulation have become research hotspots in the metabolic field. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DIET-INDUCED OBESITY ; INSULIN-RECEPTOR SUBSTRATE-1 ; ACTIVATED PROTEIN-KINASE ; FOOD-INTAKE ; TRANSCRIPTION FACTOR ; ENERGY HOMEOSTASIS ; GENE-EXPRESSION ; GLUCOSE-HOMEOSTASIS ; MAMMALIAN TARGET ; SKELETAL-MUSCLE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318127300003 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/430]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Wang ChunXia,Guo FeiFan. Branched chain amino acids and metabolic regulation[J]. CHINESE SCIENCE BULLETIN,2013,58(11):1228-1235. |
| APA | Wang ChunXia,&Guo FeiFan.(2013).Branched chain amino acids and metabolic regulation.CHINESE SCIENCE BULLETIN,58(11),1228-1235. |
| MLA | Wang ChunXia,et al."Branched chain amino acids and metabolic regulation".CHINESE SCIENCE BULLETIN 58.11(2013):1228-1235. |
入库方式： OAI收割
来源：上海营养与健康研究所
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