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Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
文献类型：期刊论文
| 作者 | Du, Ying; Meng, Qingshu; Zhang, Qian; Guo, Feifan（郭非凡）
|
| 刊名 | AMINO ACIDS
 |
| 出版日期 | 2012 |
| 卷号 | 43期号:2页码:725-734 |
| 关键词 | Isoleucine Valine Deprivation Fat loss |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | There has been a growing interest in controlling body weight by increasing dietary levels of leucine recently. By contrast, we have focused on studying the effect of deficiency of branched-chain amino acids (BCAAs) leucine on lipid metabolism. We previously have shown that mice fed a leucine-deficient diet for 7 days exhibit significant changes in lipid metabolism as demonstrated by suppressed lipogenesis in the liver and increased fat mobilization in white adipose tissue, the latter of which was found to be caused by increased lipolysis in WAT and uncoupling protein 1 expression in brown adipose tissue. The goal of our current study is to investigate whether the above effects of leucine deficiency can be generalized to the deficiency of other BCAAs including valine and isoleucine. In our current study, we show that valine or isoleucine deficiency has similar effects on reducing fat mass to leucine deprivation, in a similar manner as those observed during leucine deprivation. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | DIET-INDUCED OBESITY ; PROTEIN-SYNTHESIS ; SKELETAL-MUSCLE ; AMINO-ACIDS ; ADIPOSE-TISSUE ; PEROXISOME PROLIFERATOR ; HEMODIALYSIS-PATIENTS ; INDUCED THERMOGENESIS ; UNCOUPLING PROTEIN ; GENE-EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306365500021 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/433]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Du, Ying,Meng, Qingshu,Zhang, Qian,et al. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT[J]. AMINO ACIDS,2012,43(2):725-734. |
| APA | Du, Ying,Meng, Qingshu,Zhang, Qian,&Guo, Feifan.(2012).Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT.AMINO ACIDS,43(2),725-734. |
| MLA | Du, Ying,et al."Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT".AMINO ACIDS 43.2(2012):725-734. |
入库方式： OAI收割
来源：上海营养与健康研究所
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