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ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
文献类型：期刊论文
| 作者 | Li, Houkai; Meng, Qingshu; Xiao, Fei; Chen, Shanghai（陈上海）; Du, Ying; Yu, Junjie; Wang, Chunxia; Guo, Feifan（郭非凡）
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| 刊名 | BIOCHEMICAL JOURNAL
 |
| 出版日期 | 2011 |
| 卷号 | 438期号:2页码:283-289 |
| 关键词 | activating transcription factor 4 (ATF4) glucose tolerance hepatic steatosis high-carbohydrate diet (HCD) insulin sensitivity stearoyl-CoA desaturase 1 (SCD1) |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Chronic feeding of HCD (high-carbohydrate diet) is one of the major contributors to the prevailing of metabolic diseases. ATF4 (activating transcription factor 4) has been shown to play an important role in the regulation of glucose metabolism and obesity development; however, it is unclear how ATF4(-/-) mice respond to HCD. in the present study, we show that 8 weeks of HCD results in significant higher accumulation of TAGs (triacylglycerols) in livers and impairment in glucose tolerance in ATF4(+/+) mice, but not in ATF4(-/-) mice, compared with those on a normal diet. Meanwhile, energy expenditure is further enhanced by HCD in AM mice. Moreover, we show that ATF4 deficiency suppresses HCD-induced SCD1 (stearoyl-CoA desaturase 1) expression, furthermore, oral supplementation of the main product of SCD1 oleate (18:1) increases TAG accumulation in livers of ATF4(-/-) mice. Taken together, these results suggest that ATF4 deficiency is protective for HCD-induced hepatic steatosis and impairment of glucose tolerance and insulin sensitivity. Furthermore, the resistance to hepatic steatosis is at least in part due to suppression of SCD1 expression under HCD. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | GENE-ENVIRONMENT INTERACTIONS ; STEAROYL-COA DESATURASE-1 ; CAMP-RESPONSE ELEMENTS ; TRANSCRIPTION FACTOR ; FATTY LIVER ; INSULIN-RESISTANCE ; HEPATIC STEATOSIS ; DISEASE ; METABOLISM ; ACCUMULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295195400006 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/435]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Li, Houkai,Meng, Qingshu,Xiao, Fei,et al. ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis[J]. BIOCHEMICAL JOURNAL,2011,438(2):283-289. |
| APA | Li, Houkai.,Meng, Qingshu.,Xiao, Fei.,Chen, Shanghai.,Du, Ying.,...&Guo, Feifan.(2011).ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis.BIOCHEMICAL JOURNAL,438(2),283-289. |
| MLA | Li, Houkai,et al."ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis".BIOCHEMICAL JOURNAL 438.2(2011):283-289. |
入库方式： OAI收割
来源：上海营养与健康研究所
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