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Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in the Hypothalamus and Activating The Sympathetic Nervous System
文献类型：期刊论文
| 作者 | Cheng, Ying; Zhang, Qian; Meng, Qingshu; Xia, Tingting; Huang, Zhiying; Wang, Chunxia; Liu, Bin; Chen, Shanghai（陈上海）; Xiao, Fei; Du, Ying |
| 刊名 | MOLECULAR ENDOCRINOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 25期号:9页码:1624-1635 |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | We previously showed that leucine deprivation decreases abdominal fat mass largely by increasing energy expenditure, as demonstrated by increased lipolysis in white adipose tissue (WAT) and uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT). The goal of the present study was to investigate the possible involvement of central nervous system (CNS) in this regulation and elucidate underlying molecular mechanisms. For this purpose, levels of genes and proteins related to lipolysis in WAT and UCP1 expression in BAT were analyzed in wild-type mice after intracerebroventricular administration of leucine or corticotrophin-releasing hormone antibodies, or in mice deleted for three beta-adrenergic receptors, after being maintained on a leucine-deficient diet for 7 d. Here, we show that intracerebroventricular administration of leucine significantly attenuates abdominal fat loss and blocks activation of hormone sensitive lipase in WAT and induction of UCP1 in BAT in leucine-deprived mice. Furthermore, we provide evidence that leucine deprivation stimulates fat loss by increasing expression of corticotrophin-releasing hormone in the hypothalamus via activation of stimulatory G protein/cAMP/protein kinase A/cAMP response element-binding protein pathway. Finally, we show that the effect of leucine deprivation on fat loss is mediated by activation of the sympathetic nervous system. These results suggest that CNS plays an important role in regulating fat loss under leucine deprivation and thereby provide novel and important insights concerning the importance of CNS leucine in the regulation of energy homeostasis. (Molecular Endocrinology 25: 1624-1635, 2011) |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | CORTICOTROPIN-RELEASING HORMONE ; BROWN ADIPOSE-TISSUE ; DIET-INDUCED THERMOGENESIS ; BETA-ADRENERGIC-RECEPTORS ; FOOD-INTAKE ; DORSOMEDIAL HYPOTHALAMUS ; RESPONSIVE ELEMENT ; NEUROPEPTIDE-Y ; ENERGY-BALANCE ; BODY-WEIGHT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294344500011 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/436]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Cheng, Ying,Zhang, Qian,Meng, Qingshu,et al. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in the Hypothalamus and Activating The Sympathetic Nervous System[J]. MOLECULAR ENDOCRINOLOGY,2011,25(9):1624-1635. |
| APA | Cheng, Ying.,Zhang, Qian.,Meng, Qingshu.,Xia, Tingting.,Huang, Zhiying.,...&Guo, Feifan.(2011).Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in the Hypothalamus and Activating The Sympathetic Nervous System.MOLECULAR ENDOCRINOLOGY,25(9),1624-1635. |
| MLA | Cheng, Ying,et al."Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in the Hypothalamus and Activating The Sympathetic Nervous System".MOLECULAR ENDOCRINOLOGY 25.9(2011):1624-1635. |
入库方式： OAI收割
来源：上海营养与健康研究所
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