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ATF4 regulates lipid metabolism and thermogenesis
文献类型：期刊论文
| 作者 | Wang, Chunxia; Huang, Zhiying; Du, Ying; Cheng, Ying; Chen, Shanghai（陈上海）; Guo, Feifan（郭非凡）
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| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:2页码:174-184 |
| 关键词 | ATF4 lipid metabolism thermogenesis WAT BAT |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China. |
| 英文摘要 | Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 (UCP2) and beta-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue (WAT), suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue (BAT), suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis. |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | HORMONE-SENSITIVE LIPASE ; CAMP-RESPONSE ELEMENTS ; DIET-INDUCED OBESITY ; TRANSCRIPTION FACTOR ; ADIPOSE-TISSUE ; UNCOUPLING PROTEIN ; ENERGY-BALANCE ; TARGETED DISRUPTION ; GLUCOSE-HOMEOSTASIS ; INSULIN-RESISTANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275816100009 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/437]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Chunxia,Huang, Zhiying,Du, Ying,et al. ATF4 regulates lipid metabolism and thermogenesis[J]. CELL RESEARCH,2010,20(2):174-184. |
| APA | Wang, Chunxia,Huang, Zhiying,Du, Ying,Cheng, Ying,Chen, Shanghai,&Guo, Feifan.(2010).ATF4 regulates lipid metabolism and thermogenesis.CELL RESEARCH,20(2),174-184. |
| MLA | Wang, Chunxia,et al."ATF4 regulates lipid metabolism and thermogenesis".CELL RESEARCH 20.2(2010):174-184. |
入库方式： OAI收割
来源：上海营养与健康研究所
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