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ATF4 regulates lipid metabolism and thermogenesis

文献类型:期刊论文

作者Wang, Chunxia; Huang, Zhiying; Du, Ying; Cheng, Ying; Chen, Shanghai(陈上海); Guo, Feifan(郭非凡)
刊名CELL RESEARCH
出版日期2010
卷号20期号:2页码:174-184
关键词ATF4 lipid metabolism thermogenesis WAT BAT
通讯作者Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China.
英文摘要Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 (UCP2) and beta-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue (WAT), suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue (BAT), suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis.
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]HORMONE-SENSITIVE LIPASE ; CAMP-RESPONSE ELEMENTS ; DIET-INDUCED OBESITY ; TRANSCRIPTION FACTOR ; ADIPOSE-TISSUE ; UNCOUPLING PROTEIN ; ENERGY-BALANCE ; TARGETED DISRUPTION ; GLUCOSE-HOMEOSTASIS ; INSULIN-RESISTANCE
收录类别SCI
语种英语
WOS记录号WOS:000275816100009
公开日期2016-02-26
版本出版稿
源URL[http://202.127.25.144/handle/331004/437]  
专题中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组
推荐引用方式
GB/T 7714
Wang, Chunxia,Huang, Zhiying,Du, Ying,et al. ATF4 regulates lipid metabolism and thermogenesis[J]. CELL RESEARCH,2010,20(2):174-184.
APA Wang, Chunxia,Huang, Zhiying,Du, Ying,Cheng, Ying,Chen, Shanghai,&Guo, Feifan.(2010).ATF4 regulates lipid metabolism and thermogenesis.CELL RESEARCH,20(2),174-184.
MLA Wang, Chunxia,et al."ATF4 regulates lipid metabolism and thermogenesis".CELL RESEARCH 20.2(2010):174-184.

入库方式: OAI收割

来源:上海营养与健康研究所

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