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Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
文献类型：期刊论文
| 作者 | Cheng, Ying; Meng, Qingshu; Wang, Chunxia; Li, Houkai; Huang, Zhiying; Chen, Shanghai（陈上海）; Xiao, Fei; Guo, Feifan（郭非凡）
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| 刊名 | DIABETES
 |
| 出版日期 | 2010 |
| 卷号 | 59期号:1页码:17-25 |
| 通讯作者 | Guo, FF (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutrit Sci, Shanghai Inst Biol Sci,Grad Sch, Shanghai, Peoples R China. |
| 英文摘要 | OBJECTIVE-White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet unexpectedly experienced a dramatic reduction in abdominal fat mass. The cellular mechanisms responsible for this loss, however, are nuclear. The goal of current study is to investigate possible mechanisms. RESEARCH DESIGN AND METHODS-Male C57BL/6J mice were fed either control, leucine-deficient, or pair-fed diets for 7 days. Changes in metabolic parameters and expression of genes and proteins related to lipid metabolism were analyzed in WAT and BAT. RESULTS-We found that leucine deprivation for 7 days increases oxygen consumption, suggesting increased energy expenditure. We also observed increases in lipolysis and expression of beta-oxidation genes and decreases in expression of lipogenic genes and activity of fatty acid synthase in WAT, consistent with increased use and decreased synthesis of fatty acids, respectively. Furthermore, we observed that leucine deprivation increases expression of uncoupling protein (UCP)-1 in BAT, suggesting increased thermogenesis. CONCLUSIONS-We show for the first time that elimination of dietary leucine produces significant metabolic changes in WAT and BAT. The effect of leucine deprivation on UCP1 expression is a novel and unexpected observation and suggests that the observed increase in energy expenditure may reflect an increase in thermogenesis in BAT. Further investigation will be required to determine the relative contribution of UCP1 upregulation and thermogenesis in BAT to leucine deprivation-stimulated fat, loss. Diabetes 59:17-25, 2010 |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | DIET-INDUCED OBESITY ; HORMONE-SENSITIVE LIPASE ; SKELETAL-MUSCLE ; ADAPTIVE THERMOGENESIS ; MOLECULAR-MECHANISMS ; INSULIN-RESISTANCE ; CHOLESTEROL-METABOLISM ; BODY-WEIGHT ; AMINO-ACID ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273472500004 |
| 公开日期 | 2016-02-26 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/438]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 |
| 推荐引用方式 GB/T 7714 | Cheng, Ying,Meng, Qingshu,Wang, Chunxia,et al. Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue[J]. DIABETES,2010,59(1):17-25. |
| APA | Cheng, Ying.,Meng, Qingshu.,Wang, Chunxia.,Li, Houkai.,Huang, Zhiying.,...&Guo, Feifan.(2010).Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue.DIABETES,59(1),17-25. |
| MLA | Cheng, Ying,et al."Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue".DIABETES 59.1(2010):17-25. |
入库方式： OAI收割
来源：上海营养与健康研究所
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