Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy
文献类型：期刊论文
| 作者 | Chen, Wei-Hai1,2; Luo, Guo-Feng1,2; Lei, Qi1,2; Cao, Feng-Yi1,2; Fan, Jin-Xuan1,2; Qiu, Wen-Xiu1,2; Jia, Hui-Zhen1,2; Hong, Sheng1,2; Fang, Fang3; Zeng, Xuan1,2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2016 |
| 卷号 | 76页码:87-101 |
| 关键词 | Mesoporous silica nanoparticle Tumor-targeted Magnetic resonance imaging Theranostic Precise therapy |
| 英文摘要 | In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper beta-cyclodextrin (beta-CD) was immobilized on the surface of mesoporous silica shell via platinum(IV) prodrug linking for reduction-triggered intracellular drug release. Then Arg-Gly-Asp (RGD) peptide ligand was further introduced onto the gatekeeper beta-CD via host-guest interaction for cancer targeting purpose. After active-targeting endocytosis by cancer cells, platinum(IV) prodrug in MMSNs would be restored to active platinum(II) drug in response to the innative reducing microenvironment in cancer cells, resulting in the detachment of beta-CD gatekeeper and thus simultaneously triggering the in situ release of anticancer drug doxorubicin (DOX) entrapped in the MMSNs to kill cancer cells. It was found that with the aid of an external magnetic field, drug loaded MMSNs showed high contrast in MR imaging in vivo and exhibited magnetically enhanced accumulation in the cancer site, leading to significant inhibition of cancer growth with minimal side effects. This multifunctional MMSN will find great potential as a theranostic nanoplatform for cancer treatment. (c) 2015 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | THERANOSTIC PLATINUM(IV) PRODRUG ; GUIDED PHOTOTHERMAL THERAPY ; INTRACELLULAR DRUG-DELIVERY ; IN-VIVO ; GOLD NANOPARTICLES ; CANCER-THERAPY ; IRON-OXIDE ; SHELL ; CORE ; PLATFORM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366961100008 |
| 公开日期 | 2016-03-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9103]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China 2.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wei-Hai,Luo, Guo-Feng,Lei, Qi,et al. Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy[J]. BIOMATERIALS,2016,76:87-101. |
| APA | Chen, Wei-Hai.,Luo, Guo-Feng.,Lei, Qi.,Cao, Feng-Yi.,Fan, Jin-Xuan.,...&Zhang, Xian-Zheng.(2016).Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy.BIOMATERIALS,76,87-101. |
| MLA | Chen, Wei-Hai,et al."Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy".BIOMATERIALS 76(2016):87-101. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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