A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290
文献类型：期刊论文
| 作者 | Li, Xin1,2 ; Li, Xiao-Ming1; Zhang, Peng1,2; Wang, Bin-Gui1
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2015-12-02 |
| 卷号 | 17期号:12页码:1204-1212 |
| 关键词 | Marine alga-derived fungus Penicillium oxalicum secondary metabolites antibacterial activity anti-HAB activity |
| 英文摘要 | Ten secondary metabolites (1-10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Penicillium oxalicum EN-290. The structures of these compounds were elucidated on the basis of 1D and 2D NMR experiments and the absolute configuration of compound 2 was confirmed by electronic circular dichroism quantum calculations. Compound 1 showed potent activity against Staphylococcus aureus with an MIC value of 2.0g/ml, which is stronger than that of the positive control (chloromycetin, with an MIC 4.0g/ml). This compound also showed activity against harmful algal bloom causative species Nitzschia closterium with inhibition zones of 20, 16, and 10mm at 20, 10, and 5mg/ml, respectively. Interestingly, so far, this type of anti-HAB metabolites has only been found in the algal-derived isolate of P. oxalicum. It could probably be a defense of this fungus against environmental stress and threat of survival. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368454000012 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/95225]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xin,Li, Xiao-Ming,Zhang, Peng,et al. A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1204-1212. |
| APA | Li, Xin,Li, Xiao-Ming,Zhang, Peng,&Wang, Bin-Gui.(2015).A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1204-1212. |
| MLA | Li, Xin,et al."A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1204-1212. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。