Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7
文献类型：期刊论文
| 作者 | Chen, Songcan; Li, Xiaomin ; Sun, Guoxin; Zhang, Yingjiao; Su, Jianqiang; Ye, Jun
|
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2015-10 |
| 卷号 | 16期号:10页码:23390-23404 |
| 关键词 | LSJC7 antibiotic heavy metal resistance |
| 英文摘要 | Co-contamination of antibiotics and heavy metals prevails in the environment, and may play an important role in disseminating bacterial antibiotic resistance, but the selective effects of heavy metals on bacterial antibiotic resistance is largely unclear. To investigate this, the effects of heavy metals on antibiotic resistance were studied in a genome-sequenced bacterium, LSJC7. The results showed that the presence of arsenate, copper, and zinc were implicated in fortifying the resistance of LSJC7 towards tetracycline. The concentrations of heavy metals required to induce antibiotic resistance, i.e., the minimum heavy metal concentrations (MHCs), were far below (up to 64-fold) the minimum inhibition concentrations (MIC) of LSJC7. This finding indicates that the relatively low heavy metal levels in polluted environments and in treated humans and animals might be sufficient to induce bacterial antibiotic resistance. In addition, heavy metal induced antibiotic resistance was also observed for a combination of arsenate and chloramphenicol in LSJC7, and copper/zinc and tetracycline in antibiotic susceptible strain Escherichia coli DH5. Overall, this study implies that heavy metal induced antibiotic resistance might be ubiquitous among various microbial species and suggests that it might play a role in the emergence and spread of antibiotic resistance in metal and antibiotic co-contaminated environments. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000364232100017 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32313]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Songcan,Li, Xiaomin,Sun, Guoxin,et al. Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(10):23390-23404. |
| APA | Chen, Songcan,Li, Xiaomin,Sun, Guoxin,Zhang, Yingjiao,Su, Jianqiang,&Ye, Jun.(2015).Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(10),23390-23404. |
| MLA | Chen, Songcan,et al."Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.10(2015):23390-23404. |
入库方式： OAI收割
来源：生态环境研究中心
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