Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article
文献类型：期刊论文
| 作者 | Yang, WC; Lu, JJ; Yang, L; Zhang, JJ |
| 刊名 | IRANIAN JOURNAL OF PUBLIC HEALTH
 |
| 出版日期 | 2015 |
| 卷号 | 44期号:11页码:1445—1452 |
| 关键词 | CHINESE HAN POPULATION MATRIX METALLOPROTEINASES RISK-FACTORS GENE DISEASE INHIBITORS ATHEROSCLEROSIS SUSCEPTIBILITY EXPRESSION STIFFNESS |
| ISSN号 | 2251-6085 |
| 通讯作者 | Zhang, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China. |
| 英文摘要 | Background: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension. However, related studies yielded inconsistent or contradictory results. Methods: To evaluate the association of MMP-9 -1562C/T polymorphism with essential hypertension, we performed a meta-analysis by combining all available independent case-control studies (n=6). A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015. Results: MMP-9 -1562C/T polymorphism was associated with essential hypertension under the allelic model (T vs. C, OR=1.36, 95% CI=1.17-1.59, P<0.0001). Subsequent sensitivity analysis confirmed the stability of the results. Such association was also observed in the dominant (TT+CT vs. CC, OR=1.30, 95% CI=1.10-1.54, P=0.002) and codominant (CT vs. TT+CC, OR=1.27, 95% CI=1.05-1.53, P=0.01) models but not in the recessive model (TT vs. CT+CC, OR=1.30, 95% CI=0.50-3.36, P=0.59). Conclusion: MMP-9 -1562C/T polymorphism was associated with the risk of essential hypertension. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365537200002 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24868]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Yang, WC,Lu, JJ,Yang, L,et al. Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article[J]. IRANIAN JOURNAL OF PUBLIC HEALTH,2015,44(11):1445—1452. |
| APA | Yang, WC,Lu, JJ,Yang, L,&Zhang, JJ.(2015).Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.IRANIAN JOURNAL OF PUBLIC HEALTH,44(11),1445—1452. |
| MLA | Yang, WC,et al."Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article".IRANIAN JOURNAL OF PUBLIC HEALTH 44.11(2015):1445—1452. |
入库方式： OAI收割
来源：上海应用物理研究所
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