Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes
文献类型：期刊论文
| 作者 | Wang, YL; Yao, CJ; Li, CC; Ding, L; Liu, J; Dong, P; Fang, HP; Lei, ZD; Shi, GS; Wu, MH |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:30页码:13105—13115 |
| 关键词 | JUNCTIONAL INTERCELLULAR COMMUNICATION METAL-OXIDE NANOPARTICLES IN-VITRO SILICA NANOPARTICLES MOLECULAR-DYNAMICS EPITHELIAL-CELLS MAMMALIAN-CELLS TOXICITY TIO2 MACROPHAGES |
| ISSN号 | 2040-3364 |
| 通讯作者 | Wang, YL (reprint author), Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China. |
| 英文摘要 | To date, considerable effort has been devoted to determine the potential toxicity of nanoparticles to cells and organisms. However, determining the mechanism of cytotoxicity induced by different types of nanoparticles remains challenging. Herein, typically low toxicity nanomaterials were used as a model to investigate the mechanism of cytotoxicity induced by low toxicity nanomaterials. We studied the effect of nano-TiO2, nano-Al2O3 and nano-SiO2 deposition films on the ion concentration on a cell-free system simulating the cell membrane. The results showed that the ion concentration of K+, Ca2+, Na+, Mg2+ and SO42- decreased significantly following filtration of the prepared deposition films. More specifically, at a high nano-TiO2 concentration (200 mg L-1) and a long nano-TiO2 deposition time (48 h), the concentration of Na+ decreased from 2958.01 to 2775.72, 2749.86, 2757.36, and 2719.82 mg L-1, respectively, for the four types of nano-TiO2 studied. Likewise, the concentration of SO42- decreased from 38.83 to 35.00, 35.80, 35.40, and 35.27 mg L-1, respectively. The other two kinds of typical low toxicity nanomaterials (nano-Al2O3 and nano-SiO2) have a similar impact on the ion concentration change trend. Adsorption of ions on nanoparticles and the hydrated shell around the ions strongly hindered the ions through the nanoparticle films. The endocytosed nanoparticles could be released from the cells without inducing cytotoxicity. Hindering the ion exchange and disrupting the exocytosis process are the main factors that induce cytotoxicity in the presence of excess nano-TiO2 on the cell surface. The current findings may offer a universal principle for understanding the mechanism of cytotoxicity induced by low toxicity nanomaterials. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358615200037 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24924]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, YL,Yao, CJ,Li, CC,et al. Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes[J]. NANOSCALE,2015,7(30):13105—13115. |
| APA | Wang, YL.,Yao, CJ.,Li, CC.,Ding, L.,Liu, J.,...&Wu, MH.(2015).Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes.NANOSCALE,7(30),13105—13115. |
| MLA | Wang, YL,et al."Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes".NANOSCALE 7.30(2015):13105—13115. |
入库方式： OAI收割
来源：上海应用物理研究所
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